Dyax Corporation

Henk Pieters

Rene Hoet

Clive R Wood

Daniel T Dransfield

Robert Charles Ladner

Simon E Hufton

Laetitia Devy

Maria Henderikx

René Hoet

Robert C Ladner

Proteins that bind to matrix metalloproteinase 14 and methods of using such proteins are described.

Method for treating breast cancer using antibody binding to MMP-14

Metalloproteinase binding proteins

Tie1 and Tie2 are receptor tyrosine kinase proteins that include a transmembrane domain. Tie1 and Tie2 are present on endothelial cells. This disclosure describes agents, such as antibodies, that bind to Tie1, Tie2, and Ang, including ones that inhibit endothelial cell activity.

Antibodies to Tie1 ectodomain

Antibodies that bind MMP-14

Tie1 and Tie2 are receptor tyrosine kinase proteins that include a transmembrane domain. Tie1 and Tie2 are present on endothelial cells. This disclosure describes agents, such as antibodies, that bind to Tie1, Tie2, and Ang, including ones that inhibit endothelial cell activity and angiogenesis. The agents can be used to treat angiogenesis-associated disorders.

Method of inhibition of vascular development using an antibody

Tie1 is a receptor tyrosine kinase protein that includes a transmembrane domain. Tie1 is present on endothelial cells. This disclosure described antibodies that bind to Tie1, including ones that inhibit endothelial cell activity.

Tie1-binding ligands

Growing community of inventors

Maastricht, Netherlands

Henk Pieters