Merck Sharp + Dohme B.v.

Msd Oss B.v.

Henk Jan Out

Wouter De Graaff

Rudolf Johannes Joseph Groenewegen

Rudolf Johannes Joseph NV Organon Groenewegen

The subject invention provides a drug delivery system comprising at least one compartment consisting of (i) a drug-loaded thermoplastic polymer core, (ii) a drug-loaded thermoplastic polymer intermediate layer and (iii) a non-medicated thermoplastic polymer skin covering the intermediate layer, wherein said intermediate layer is loaded with (a) crystals of a first pharmaceutically active compound and with (b) a second pharmaceutically active compound in dissolved form and wherein said core is loaded with said second compound in dissolved form.

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Oss, Netherlands

Henk Jan Out