Edwards Lifesciences Corporation

Becton Dickinson and Company Limited

Valtech Cardio Ltd.

Edwards Lifesciences Innovation (israel) Ltd.

Edwards Lifesciences Innovation Ltd.

Hengchu Cao

Eric Robert Dixon

Douglas Thomas Dominick

Sergio Delgado

Jensen Chen

Guillermo W Moratorio

Ralph Schneider

Brian S Conklin

Manouchehr A Miraki

Lauren R Freschauf

James A Davidson

Grace Myong Kim

Paul A Schmidt

Wei Sun

Mohammad Jafari

Hoa Trinh Tran

Kristy Luong Tam

Tal Reich

David Maimon

Yaron Keidar

Liron Tayeb

Eran Goldberg

Eitan Atias

Ming H Wu

Adi Carmi

Shih-Hwa Shen

Arie Tylis

Nima V Nia

Krystal Ya-Fong Lai

Holly Kung Jung Hsu

Stanton J Rowe

Assaf Bash

Tomer Saar

Dustin P Armer

Michael G Valdez

Ofir Witzman

Eason Michael Abbott

Michael D Franklin

Feras Al Hatib

John Joseph Desrosiers

Noa Axelrod

Anatoly Dvorsky

Amir Blumenfeld

Daniel James Murray

Brian Ray Hipszer

Bingquan Su

Sakyasingh Tripathy

Cole Emerson Feagler

Manoucher A Miraki

Amanda Tjipta Sugijoto

Disclosed is a delivery device, kit, system, method, etc. for localized fusion of leaflets of a tissue valve, for example, a native heart valve, using an adhesive. The delivery device can have one or more capture features for capturing separate leaflets, for example, the anterior and posterior mitral leaflets. An applicator can be configured to apply a biocompatible adhesive between the captured leaflets, and one or more curing elements can be configured to cure the applied biocompatible adhesive. The kit can have the aforementioned delivery device, and the biocompatible adhesive used therewith. The method can include positioning the aforementioned delivery device adjacent the anterior and posterior mitral leaflets, capturing the mitral leaflets between the paddles of the delivery device, applying a biocompatible adhesive between the captured mitral leaflets via the applicator, and curing the applied biocompatible adhesive via the energy elements to locally fuse the mitral leaflets.

Localized fusion of native leaflets using activated adhesive

Described herein are thermal mass flow sensors that combine calorimetric and anemometric (e.g., hot-wire) elements to provide a hybrid approach to determining flow rate of a liquid. The flow probes or flow sensors are configured to use a heater to apply heat to a thermally-conducting material in contact with the flowing liquid, to measure a temperature of the thermally-conducting material upstream of the heater and downstream or at the heater, to adjust power to the heater to achieve a targeted temperature difference, and to determine a flow rate based at least in part on the power supplied to the heater and the measured temperatures. This approach provides flow rate due at least in part to the fluid cooling the thermally-conductive material proportionate to flow rate with non-linear effects. This hybrid approach can provide accurate readings of flow rates of liquids delivered through an IV line to a patient.

Thermal mass fluid flow sensor

Methods, systems, and apparatuses for treating a heart are provided. Methods can include obtaining and using an implant. One or more catheters can be used to properly position and attach the implant in a desired location in a chamber of the heart, for example, such that (i) a first portion of the implant is anchored to a first site on a wall of the chamber, (ii) a second portion of the implant is anchored to a second site on the wall of the chamber, (iii) a mid-portion of the implant extends in a curved path along the wall of the chamber between the first site and the second site, and (iv) an elongate contraction member of the implant cuts across the chamber between the first site and the second site. Other embodiments are described.

Cinching of dilated heart muscle

An expandable docking station includes an annular valve seat having an end, an annular outer wall comprising struts disposed around the valve seat, and links that connect the end of the annular valve seat to the annular outer wall. Each of the links extends from the struts of the annular outer wall directly toward a longitudinal axis that runs longitudinally through a center of the docking station, and to a corresponding one of a plurality of circumferentially spaced axially extending legs at least partially defining the annular valve seat. The outer wall is configured to conform to an interior shape of a blood vessel, when expanded inside the blood vessel, such that the outer wall can expand in multiple locations to conform to multiple bulges of the blood vessel and can contract in multiple locations to conform to multiple narrowed regions of the blood vessel.

Docking stations for transcatheter valves

In one embodiment, a leaflet capture device for improving the coaptation of heart valve leaflets is provided. The leaflet capture device can include a clip having a coupling member and a leaflet engagement portion. The coupling member has a lumen extending therethrough. The leaflet engagement portion is moveable toward and away from the coupling member. The leaflet capture device can be delivered by a support catheter, an inner shaft, and an actuating connector. Extending an end of the inner shaft away from the coupling member of the clip pulls the actuating connector to move the leaflet engagement portion away from the coupling member.

Heart valve coaptation device

Some disclosed suture securement devices comprise a flat, thin, generally planar body that has one or more suture engagement slots extending into the body from a perimeter inlet for receiving sutures laterally into the device. The slots can be resiliently widened to receive a suture and then released to clamp onto the suture. Some embodiments include two or more such suture engagement slots that independently receive and secure different sutures. Some embodiments include one or more locking tabs that have a closed position that retains the slots against widening and blocks the inlet to the slot. In some embodiment two or more slots are position next to each other on the same side of the device, while in other embodiments slots are positioned on opposite sides of the device. Other types of suture securement devices are also disclosed.

Suture securement devices

Disclosed prosthetic valves can comprise a sewing ring configured to secure the valve to an implantation site. Some disclosed valves comprise a resiliently collapsible frame having a neutral configuration and a collapsed deployment configuration. Some disclosed frames can self-expand to the neutral configuration when released from the collapsed deployment configuration. Collapsing a disclosed valve can provide convenient access to the sewing ring, such as for securing the valve to the implantation site, as well as for the insertion of the valve through relatively small surgical incisions.

Methods for manufacturing resilient prosthetic surgical heart valves

Docking stations for transcatheter valves are described. The docking stations can include an expandable frame, at least one sealing portion, and a valve seat. The expandable frame can be configured to conform to an interior shape of a portion of the circulatory system when expanded inside the circulatory system. The sealing portion can be configured to contact an interior surface of the circulatory system to create a seal. The valve seat can be connected to the expandable frame and can be configured to support an expandable transcatheter valve. The docking stations are adaptable to different anatomies/locations to allow implantation of a transcatheter valve in a variety of anatomies/locations.

A low pressure gradient prosthetic heart valve for implant in a human. The valve includes a support frame with undulating inflow cusps and outflow commissure posts to which flexible leaflets attach and coapt in a flow area. The commissure posts angle outward in a neutral state to widen the outflow orifice area. Also, the leaflets are designed to fit within the support frame and expand outward in a valve open state without creating a shelf or belly that would restrict flow.

Low gradient prosthetic heart valves

An implantable prosthetic device includes a coaption portion, paddles, and clasps. The paddles are moveable from a closed position to an open position. The clasps are also moveable from an open position to a closed position. The implantable prosthetic device can be used to repair a native valve, such as a native mitral valve. Other embodiments are also described.

Heart valve sealing devices and delivery devices therefor

Methods, systems, and apparatuses for treating a heart are provided. Methods can include obtaining and using an implant. One or more catheters can be used to properly position and attach the implant in a desired location in a chamber of the heart, for example, on a ventricular wall of the left ventricle between one or more papillary muscles of the left ventricle and the annulus. Then a distance along the implant or a region of the heart, for example, between the papillary muscle and the annulus, can be reduced by contracting the implant along its longitudinal axis by applying tension to a contraction member of the implant. Other embodiments are described.

An implantable prosthetic device includes a coaption portion, paddles, and clasps. The paddles are extendable from a folded closed position to an open position. The clasps each have a fixed arm and a plurality of moveable arms each having a barbed portion. A plurality of hinge portions connect the moveable arms to the fixed arm.

An implantable prosthetic device includes a coaption portion, paddles, and clasps. The paddles are extendable from a folded closed position to an open position. A clasp is attached to each of the paddles. The clasps have a fixed arm attached to the paddle and a moveable arm. The moveable arm has a barbed portion, a first eyelet, and a second eyelet. The hinge portion connects the fixed arm to the moveable arm. A first intermediate suture loop is attached to the first eyelet and a second intermediate suture loop is attached to the second eyelet. At least one actuation suture is attached to the first and second intermediate suture loops.

An implantable prosthetic device includes a coaption portion, paddles, and clasps. The paddles are extendable from a folded closed position to an open position. A clasp is attached to each of the paddles. Each clasp has a fixed arm attached to the inner portion of the paddle and a moveable arm having a barbed portion. A hinge portion connects the fixed arm to the moveable arm. A cover wraps around at least a portion of the moveable arm of the clasp. At least one actuation suture is attached to the cover.

Growing community of inventors

Irvine, CA, United States of America

Hengchu Cao