Xenogen Corporation

Heng Xu

Bradley W Rice

Chaincy Kuo

Daniel G Stearns

Described herein are systems and methods for spectral unmixing of in vivo light data. The spectral unmixing separates image data according to spectra from multiple internal light sources in an effort to isolate one or more spectrum of interest. The spectral unmixing obtains images with a combination of different and known excitation and emission limits. The spectral unmixing then uses an iterative solution process to separate spectra for the multiple fluorescent light sources, and provides a spectrum and/or a spatial distribution map for at least one of the internal light sources.

Spectral unmixing for in-vivo imaging

The invention relates to topographic construction that combines photographic and structured light information. The dual modality construction acquires structured light information for an object and photographic images from multiple views about the object. Topographic construction then processes the structured light information and photographic data in the multiple images to generate a surface representation of the object in each modality. The photographic and structured light surface representations are then combined to output a dual modality surface topography.

Surface construction using combined photographic and structured light information

Described herein are systems and methods for obtaining a three-dimensional (3D) representation of the distribution of fluorescent probes inside a sample, such as a mammal. Using a) fluorescent light emission data from one or more images, b) a surface representation of the mammal, and c) computer-implemented photon propagation models, the systems and methods produce a 3D representation of the fluorescent probe distribution in the mammal. The distribution may indicate&#x2014;in 3D&#x2014;the location, size, and/or brightness or concentration of one or more fluorescent probes in the mammal.

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Alameda, CA, United States of America

Heng Xu