Bionime Gmbh

Heng-Chia Chang

Chun-Mu Huang

Chieh-Hsing Chen

Chi-Hao Chen

Chien-Chung Chen

Pi-Hsuan Chen

A method for manufacturing an implantable micro-biosensor includes the steps of: a) providing a substrate, b) forming on a first surface of the substrate a first working electrode which at least includes a first sensing section including a first conductive material, c) forming on the first surface of the substrate at least one second working electrode which at least includes a second sensing section disposed proximate to at least one side of the first sensing section, and d) forming a chemical reagent layer which at least covers the first conductive material of the first sensing section and which reacts with the analyte to produce a product.

Method for manufacturing implantable micro-biosensor

The present invention provides a measuring method for prolonging a usage lifetime of a biosensor to measure a physiological signal representative of a physiological parameter associated with an analyte in a biofluid. The biosensor includes two working electrodes at least partially covered by a chemical reagent and two counter electrodes having silver and a silver halide, and each silver halide has an initial amount. The measuring method includes cyclic steps of: applying a measurement voltage to drive one of the two working electrodes at a measurement period to measure the physiological signal, thereby obtaining the physiological parameter, wherein the silver halide of one of the two working electrodes is consumed by a consumption amount; stopping applying the measurement voltage; and applying a replenishment voltage to drive the consumed counter electrode at a replenishment period to replenish the silver halide of a recharge amount to the consumed counter electrode, wherein: whenever the physiological parameter is obtained, a guarding value of a sum of the recharge amount and the initial amount subtracting the consumption amount is controlled within a range of the initial amount plus or minus a specific value.

Micro biosensor and measuring method thereof

An implantable micro-biosensor a substrate, a first electrode, a second electrode, a third electrode, and a chemical reagent layer. The first electrode is disposed on the substrate and used as a counter electrode. The second electrode is disposed on the substrate and spaced apart from the first electrode. The third electrode is disposed on the substrate and used as a working electrode. The chemical reagent layer at least covers a sensing section of the third electrode so as to permit the third electrode to selectively cooperate with the first electrode or the first and second electrodes to measure a physiological signal in response to the physiological parameter of the analyte.

Implantable micro-biosensor and method for manufacturing the same

The present invention provides a micro biosensor for reducing a measurement interference when measuring a target analyte in the biofluid, including: a substrate; a first working electrode configured on the surface, and including a first sensing section; a second working electrode configured on the surface, and including a second sensing section which is configured adjacent to at least one side of the first sensing section; and a chemical reagent covered on at least a portion of the first sensing section for reacting with the target analyte to produce a resultant. When the first working electrode is driven by a first working voltage, the first sensing section measures a physiological signal with respect to the target analyte. When the second working electrode is driven by a second working voltage, the second conductive material can directly consume the interferant so as to continuously reduce the measurement inference of the physiological signal.

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Taichung, Taiwan

Heng-Chia Chang