Umc Utrecht Holding B.v.

Pirche Ag

Hendrikus Theodorus Spierings

Ralf Schliehe-Diecks

The invention relates to a method, system and/or data structure for carrying out a computer implemented method for determining the numbers of predicted indirectly recognized HLA epitopes (PIRCHES) between one or more donors and one or more recipients of transplantation material. The method, system and data structure described herein allow the identification of permissible mismatches and therefore relatively safe transplantation material by analyzing via a computer implemented method HLA-derived peptides of patient and donor.

Methods and systems for predicting alloreactivity in transplantation

Disclosed is a method for prediction of an immune response against human leukocyte antigens (HLA) after transplantation, said method comprising HLA-typing of the donor and/or donor material and recipient to determine HLA-mismatches and determination of the number of predicted indirectly recognized HLA epitopes (PIRCHES). In particular, methods for selecting and/or screening donor material for allogeneic transplantation, for example for selecting donor material with permissible mismatches from mismatched unrelated donors and pre-transplantation prediction of an unwanted alloreactivity that could occur after transplantation of hematopoietic stem cells, cord blood, kidneys and/or other cells, tissues or organs are disclosed.

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EG Zeist, Netherlands

Hendrikus Theodorus Spierings