Applied Imaging Corporation

Kreatech Biotechnology B.v.

501 Rijksuniversiteit Leiden

Hendrikus Johannes Tanke

Hendrik Jan Houthoff

Robert Jochem Heetebrij

Herman Hendricus Volkers

Kevin Shields

Hendrik-Jan Houthoff

Jan Bonnet

Johan S Ploem

Johannes C Slats

R P M Van Gijlswijk

Anton Klaas Raap

Mark Gregson

Padraig S O'Kelly

Willem C R Sloos

Wilhelmina E Mesker

Johannes Vrolijk

Nico Peter Verwoerd

Robertus Petrus Maria Van Gijswijk

Scanning and analysis of cytology and histology samples uses a flatbed scanner to capture images of the structures of interest such as tumor cells in a manner that results in sufficient image resolution to allow for the analysis of such common pathology staining techniques as ICC (immunocytochemistry), IHC (immunohistochemistry) or in situ hybridization. Very large volumes of such material are scanned in order to identify cells or clusters of cells which are positive or warrant more detailed examination, and if analysis at higher resolution is necessary, information regarding these positive events is transferred to a secondary microscope, such as a conventional scanning microscope, to allow further analysis and review of the selected regions of the slide containing the sample.

Automated scanning method for pathology samples

The Invention relates to a method for providing at least one selected sequence in a nucleic acid with interstrand cross-links. The method comprises hybridizing at least one selected single strand sequence with a complementary single strand nucleic acid or a functional analogue thereof. The selected sequence or complementary nucleic acid or both comprise a cross-linking agent. The invention also relates to a method, referred to as COBRA, for the labeling of a set of at least two bio-organic molecules with a set of at least two colors, comprising generating said set of colors through combining ratio labeling with binary labeling.

Applications with and methods for producing selected interstrand cross-links in nucleic acids

Inorganic phosphor labelled macromolecules; a process for their

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Rijnsburg, Netherlands

Hendrikus Johannes Tanke