Dsm IP Assets B.v.

Hendrikus Bernardus Carolus Hillebrand

Evert Tjeerd Van Rij

Martine Spaans

The invention provideshost cell deficient in the production of a neutral protease and of a alkaline protease which host cell comprises a nucleic acid construct, wherein the nucleic acid construct comprises a polynucleotide encoding a compound of interest or encoding a compound involved in the synthesis of a compound of interest operably linked to a promoter sequence allowing for expression of the polynucleotide in the host cell, wherein the promoter comprises a bacteriophage promoter sequence, more preferably a bacteriophage SPO1 promoter sequence. Said host cell can advantageously be used in a method of production of a compound of interest.

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Echt, Netherlands

Hendrikus Bernardus Carolus Hillebrand