Dsm IP Assets B.v.

Technische Universiteit Delft

Isobionics B.v.

Hendrik Wouter Wisselink

Jacobus Thomas Pronk

Antonius Jeroen Adriaan Van Maris

Rene Marcel De Jong

Paul Klaassen

Hendrik Jan Bosch

Johannes Pieter Van Dijken

Victor Gabriel Guadalupe Medina

Aaron Adriaan Winkler

Martinus Julius Beekwilder

Georg Friedrich Lentzen

Adèle Margaretha Maria Liduina Van Houwelingen

Elena Melillo

Johannes Hendrik Winde

Johannes Hendrik De Winde

Jacobus Thomas Jan Pronk

The invention is directed to a santalene synthase, to a nucleic acid encoding said santalene synthase, to an expression vector comprising said nucleic acid, to a host cell comprising said expression vector, to a method of preparing santalene, to a method of preparing santalol and to a method of preparing a santalene synthase. The invention is further directed to an antibody specific for the santalane synthase.

Santalene synthase

The invention relates to a recombinant yeast cell, in particular a transgenic yeast cell, functionally expressing one or more recombinant, in particular heterologous, nucleic acid sequences encoding ribulose-1,5-biphosphate carboxylase oxygenase (Rubisco) and phosphoribulokinase (PRK). The invention further relates to the use of carbon dioxide as an electron acceptor in a recombinant chemotrophic micro-organism, in particular a eukaryotic micro-organism.

Recombinant yeast expressing rubisco and phosphoribulokinase

The present invention relates to a yeast cell comprising one or more exogenous genes of a pentose metabolic pathway non-native to the yeast cell wherein the yeast cell has a disruption of the hxk1, hxk2 glk1 and gal1 native in the yeast cell. The invention further relates to pentose and glucose fermenting yeast cell that is capable of simultaneous pentose and glucose consumption.

Pentose and glucose fermenting yeast cell

The invention relates to an eukaryotic cell expressing nucleotide sequences encoding the ara A, ara B and ara D enzymes whereby the expression of these nucleotide sequences confers on the cell the ability to use L-arabinose and/or convert L-arabinose into L-ribulose, and/or xylulose 5-phosphate and/or into a desired fermentation product such as ethanol. Optionally, the eukaryotic cell is also able to convert xylose into ethanol.

Metabolic engineering of arabinose-fermenting yeast cells

The invention relates to a polypeptide having a mutation at one or more position corresponding to T219 of SEQ ID NO: 55, wherein the polypeptide has at least 50% sequence identity with SEQ ID NO: 55, and wherein the polypeptide has permease activity.

Polypeptides with permease activity

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Culemborg, Netherlands

Hendrik Wouter Wisselink