Koninklijke Philips Corporation N.v.

B. Braun Melsungen Ag

Hendrik Roelof Stapert

Ameet Kumar Jain

Stefan Van De Pas

Kunal Vaidya

Derk Jan Wilfred Klunder

Willem-Jan Arend De Wijs

Johan George Kloosterboer

Emile Johannes Karel Verstegen

Dirk Jan Broer

Helmar Van Santen

Francois Guy Gerard Marie Vignon

Shyam Bharat

Ramon Quido Erkamp

Jacobus Hermanus Maria Neijzen

Harm Jan Willem Belt

Alvin Chen

Mischa Megens

Maarten Marinus Johannes Wilhelm Van Herpen

Mark Thomas Johnson

Maarten Marinus Johannes Wilhelmus Van Herpen

Johannes Wilhelmus Weekamp

Menno Willem Jose Prins

Vincentius Paulus Buil

Emiel Peeters

Anke Pierik

Lutz Christian Gerhardt

Franciscus Hendrikus Van Heesch

Fredericus Johannes Touwslager

Niels Nijhof

Elise Claude Valentine Talgorn

Cornelis Gerardus Visser

Marc Wilhelmus Gijsbert Ponjee

Jacob Marinus Jan Den Toonder

Pippinus Maarten Robertus Wortelboer

Menno W J Prins

Natallia Eduardauna Uzunbajakava

Derk J W Klunder

Timon Rutger Grob

Jeroen Kortsmit

Maarten M J W Van Herpen

Mustafa Hakan Gökgürler

Gerardus Franciscus Cornelis Maria Lijten

Ralph Theodorus Hubertus Maessen

Mustafa Hakan Gokgurler

Maarten Van Herpen

Njin-Zu Chen

Erik Robbert Vossenaar

Jacob M J Den Toonder

Eric Franciscus Johannes Claessens

Carina Snijder

Gunther Lamparter

Carina Snuder

Mathias Thorenz

Francois Guy Gérard Marie Vignon

Maarten MJW Van Herpen

Marc W G Ponjee

Derk JW Klunder

Sibo Li

Molly Lara Flexman

Mckee Dunn Poland

Alyssa Torjesen

Mustafa Hakan GÖKGÜRLER

Jan Willem Belt

Yuichi Shibayama

An acoustic imaging apparatus and method receive a sensor signal from a passive sensor disposed on a surface of an intervention device which is disposed in an area of interest, wherein the passive sensor is located at a fixed distance from the tip of the intervention device. A processor is configured to ascertain an estimated range of locations of the tip of the intervention device in an image plane by using the sensor signal and an estimated effective distance, projected onto the image plane, from the passive sensor to the tip of the intervention device.

System and method for estimating location of tip of intervention device in acoustic imaging

The present invention relates to a system for indicating a position of an interventional device feature () of an interventional device () respective an image plane () defined by an ultrasound imaging probe () of a beamforming ultrasound imaging system () in which the position of the interventional device feature () is determined based on ultrasound signals transmitted between the ultrasound imaging probe () and an ultrasound transducer () attached to the interventional device at a predetermined distance (Lp) from the interventional device feature (). An icon providing unit (IPU) provides a first icon (Cde) indicative of a circular zone with a radius corresponding to the predetermined distance (Lp). The first icon (Cde) is displayed in a fused image that includes a reconstructed ultrasound image (RUI) from the beamforming ultrasound imaging system.

Tracking a feature of an interventional device

System () for determining a position of an interventional device () respective an image plane () defined by an ultrasound imaging probe (). The position is determined based on ultrasound signals transmitted between the ultrasound imaging probe () and an ultrasound transducer () attached to the interventional device (). An image reconstruction unit (IRU) provides a reconstructed ultrasound image (RUI). A position determination unit (PDU) computes a lateral position (LAP) of the ultrasound transducer () respective the image plane () based on a time of flight (TOF) of a maximum detected intensity (I) ultrasound signal. The position determination unit (PDU) also computes an out-of-plane distance (D) between the ultrasound transducer () and the image plane (). Computing the out-of-plane distance (D) involves comparing the maximum detected intensity (I) with a model (MO) describing an expected variation of in-plane maximum detected intensity (I) with time of flight.

Tracking an interventional device within an ultrasound image plane

System () for determining a position of an interventional device () respective an image plane () defined by an ultrasound imaging probe (). The position is determined based on ultrasound signals transmitted between the ultrasound imaging probe () and an ultrasound transducer () attached to the interventional device (). An image reconstruction unit (IRU) provides a reconstructed ultrasound image (RUI). A position determination unit (PDU) computes a position (LAP) of the ultrasound transducer () respective the image plane (). The position determination unit (PDU) indicates the computed position (LAP) in the reconstructed ultrasound image (RUI). The position determination unit (PDU) suppresses the indication of the computed position (LAP) under specified conditions relating to the computed position (LAP) and the ultrasound signals.

Interventional device positioning relative to an ultrasound image plane

The present invention relates to an ultrasound-based system for localizing a medical device within the field of view of an ultrasound imaging probe. A localization system is provided that includes at least three ultrasound emitters that are arranged on a frame; and a position triangulation unit. The frame is adapted for attachment to an ultrasound imaging probe. The position triangulation unit determines a spatial position of the ultrasound detector relative to the at least three ultrasound emitters based on signals received from an ultrasound detector that is attached to the medical device. The frame includes a detachable reference volume comprising a background volume and an inclusion or void. When the detachable reference volume is attached to the frame and the frame is attached to the ultrasound imaging probe the inclusion or void provides a corresponding image feature within the field of view of the ultrasound imaging probe for use in calibrating the field of view of the ultrasound imaging probe with the coordinate system of the localization system.

Ultrasound based tracking system using triangulation and spatial positioning with detachable reference frame and ultrasound emitters

The present invention relates to an apparatus for tracking a position of an interventional device respective an image plane of an ultrasound field. The position includes an out-of-plane distance (Dop). A geometry-providing unit (GPU) includes a plurality of transducer-to-distal-end lengths (Ltde), each length corresponding to a predetermined distance (Ltde) between a distal end of an interventional device and an ultrasound detector attached to the interventional device, for each of a plurality of interventional device types (T). An image fusion unit (IFU) receives data indicative of the type (T) of the interventional device being tracked; and based on the type (T): selects from the geometry-providing unit (GPU), a corresponding transducer-to-distal-end length (Ltde); and indicates in a reconstructed ultrasound image (RUI) both the out-of-plane distance (Dop) and the transducer-to-distal-end length (Ltde) for the interventional device within the ultrasound field.

Interventional device recognition

A controller () for simultaneously tracking multiple interventional medical devices includes a memory () that stores instructions and a processor () that executes the instructions. When executed by the processor (), the instructions cause the controller to execute a process that includes receiving timing information from a first signal emitted from an ultrasound probe () and reflective of timing when the ultrasound probe () transmits ultrasound beams to generate ultrasound imagery. The process executed by the controller also includes forwarding the timing information to be available for use by a first acquisition electronic component (). The first acquisition electronic component () also receives sensor information from a first passive ultrasound sensor (S) on a first interventional medical device (). The timing information is used to synchronize the sensor information from the first passive ultrasound sensor (S) on the first interventional medical device () with sensor information from a second passive ultrasound sensor (S) on a second interventional medical device ().

Synchronized tracking of multiple interventional medical devices

An interventional device includes an elongate shaft and a transducer strip. The transducer strip includes a first edge and an opposing second edge. The first edge and the second edge are separated by a width dimension, and the first edge and the second edge each extend along a length direction of the transducer strip. The transducer strip also includes a piezoelectric transducer that extends along a transducer direction that forms an acute angle with respect to the length direction. The transducer strip is wrapped in the form of a spiral around the elongate shaft of the interventional device such that the piezoelectric transducer forms a band around the elongate shaft. The width dimension is defined such that the adjacent first and second edges of consecutive turns of the spiral abut or overlap one another.

Interventional device with piezoelectric transducer

Ultrasound based tracking

The present invention relates to an apparatus () for tracking a position of an interventional device () respective an image plane () of an ultrasound field. The position includes an out-of-plane distance (Dop). A geometry-providing unit (GPU) includes a plurality of transducer-to-distal-end lengths (Ltde), each length corresponding to a predetermined distance (Ltde) between a distal end () of an interventional device () and an ultrasound detector () attached to the interventional device, for each of a plurality of interventional device types (T). An image fusion unit (IFU) receives data indicative of the type (T) of the interventional device being tracked; and based on the type (T): selects from the geometry-providing unit (GPU), a corresponding transducer-to-distal-end length (Ltde); and indicates in a reconstructed ultrasound image (RUI) both the out-of-plane distance (Dop) and the transducer-to-distal-end length (Ltde) for the interventional device within the ultrasound field.

The invention relates to detection the presence of a target molecule in a sample, wherein the sample is contacted with a substrate, the substrate subsequently being washed in a wash step. In particular, the invention relates to a method of detecting the presence of a target molecule in a sample, the method comprising: (a) contacting the sample () with a substrate having immobilized thereon probe molecules that specifically binds to the target molecule; (b) washing the substrate () in a wash step by a wash fluid in order to remove or dilute unbound target molecules; (c) detect the presence of resultant binding complexes () on the substrate to determine whether the target molecule is present in the sample&#x2014;The wash fluid being substantially refractive index matched to the substrate.

Detecting target molecules in a sample

The invention relates to detection the presence of a target molecule in a sample, wherein the sample is contacted with a substrate, the substrate subsequently being washed in a wash step. In particular, the invention relates to a method of detecting the presence of a target molecule in a sample, the method comprising: (a) contacting the sample () with a substrate having immobilized thereon probe molecules that specifically binds to the target molecule; (b) washing the substrate () in a wash step by a wash fluid in order to remove or dilute unbound target molecules; (c) detect the presence of resultant binding complexes () on the substrate to determine whether the target molecule is present in the sample. The wash fluid being substantially refractive index matched to the substrate.

The present invention relates to a method for immobilizing nucleic acids on a support, comprising the provision of a nucleic acid with a stretch of nucleotides of only one basetype and the immobilization of said nucleic acid on a support by crosslinking by light, wherein said crosslinking by light is performed at a wavelength of about 300-500 nm, preferably at a wavelength of 365 nm. The present invention further relates to a method for the analysis of nucleic acids immobilized according to the invention, which comprises the hybridization of the immobilized nucleic acid with complementary and mismatch segments. Furthermore, the present invention relates to immobilized nucleic acids obtainable by the method of the invention, the use of accordingly immobilized nucleic acids for the production of nucleic acid arrays and a diagnostic kit, comprising an array of nucleic acids which are immobilized according to the present invention.

Method for immobilizing nucleic acids on a support

A luminescence sensor, comprising a non-transparent substrate structure () having at least one aperture () intended to comprise an analyte and a transparent substrate structure (), which is arranged to or adjacent said first structure (). The aperture has a smallest lateral dimension, which is smaller than half the effective wavelength of an excitation radiation, such as light at a wavelength of 700 nm, resulting in an effective wavelength in water of about 538 nm. The transparent structure has a trench () with a surface portion provided with ligands with an affinity towards a target molecule. The trench results in that a luminophore attached to the target molecule will be positioned at the entrance surface of the aperture, where the excitation energy is largest.

Aperture biosensor with trenches

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Eindhoven, Netherlands

Hendrik Roelof Stapert