Akzona Incorporated

Ciba-geigy Corporation

Akzo N.v.

Hendrik M Greven

David De Wied

Bruno Kamber

Peter Sieber

Bernhard Riniker

Werner Rittel

Max Brugger

Robert Neher

Friedrich Werner Kahnt

Herbert Zuber

The invention relates to polypeptides, in particular to penta- and hexapeptides, characterized by the general formula I: ##STR1## or a functional derivative thereof, wherein Z represents hydrogen or NH.sub.2,

Peptides

The present invention is dealing with a pharmaceutical composition containing a peptide of the formula:

Biologically active peptides

The present invention relates to novel psycho-pharmacological active peptides and peptide derivatives of the formula:

Psycho-pharmacological peptides

Novel and biologically useful peptides of the formula: A.sub.1 -A.sub.2 -L-Phe-X-L-Thr-L-Ser-R.sub.1 -Y-L-Ser-R.sub.2 -L-Thr-L-Pro-L-Leu-L-Val-L-Thr-B are disclosed (together with pharmaceutical compositions comprising a pharmaceutically effective amount of same) wherein:

Psychopharmacological peptides

Novel peptides of the formula ##STR1## are disclosed (together with pharmaceutical compositions comprising a pharmaceutically effective amount of same) wherein X.sub.1 and X.sub.2 represent an hydroxy or amino group and B represents:

Psychopharmacological peptides suitable for therapeutic administration

The new hypocalcaemically active peptides of formula I ##STR1## and corresponding compounds in which one or more of the asparagine and glutamic acid radicals are replaced by the aspartic acid or glutamic acid radical and/or the aspartic acid radical is replaced by the asparagine radical, their dimers, especially those in which 2 identical peptide sequences (1-32 and 1'-32') are joined in an anti-parallel arrangement via the cysteine radicals 1,7' and 7,1' by means of a disulfide bond, and derivatives are useful as hypocalcaemic agents and are prepared by splitting off groups protecting at least one amino or one carboxyl group or oxidizing the corresponding sulfides to the disulfides or condensing together adequate peptides.

Peptides and process for their manufacture

Biologically active novel peptide compounds are disclosed of the formula

Peptide derivatives and pharmaceutical compositions containing same

Biologically active novel peptides and peptide-derivatives of the general formula: ##STR1## where A represents H-(L or D)Met, H-(L or D)Met(.fwdarw.O), H-(L or D)Met(.fwdarw.O.sub.2)

Growing community of inventors

Heesch, Netherlands

Hendrik M Greven