Kreatech Diagnostics

Kreatech Biotechnology B.v.

Linxis B.v.

Hendrik Jan Houthoff

Jan Reedijk

Robert Jochem Heetebrij

Tinka Jelsma

Herman Hendricus Volkers

Remco Maria Van Es

Franciscus Michiel Van Den Berg

Marieke Johanna Bloemink

Hendrikus Johannes Tanke

Edwin Leo Lempers

Augustinus A M S Van Dongen

Niels Jurriaan Sijbrandi

Pranab Khumar Das

Dennis Christian Johannes Waalboer

Sytze Jan Buwalda

Robbert Jan Kok

Anton Klaas Raap

Paulus Martinus Petrus Van Bergen En Henegouwen

Joey Armand Muns

Jan Hendrik Schooten

Sebas Daniël Pronk

Robertus Petrus Maria Van Gijswijk

A first aspect of the disclosure relates to a method for preparing cell-targeting conjugates by coupling at least one functional moiety, such as a therapeutic compound, diagnostic compound or chelating agent to a targeting moiety. A second aspect of this disclosure relates to the cell-targeting conjugates obtainable with this method. A third aspect of the disclosure described herein relates to pharmaceutical compositions comprising the cell-targeting conjugates.

Method for preparing cell targeting conjugates, and the complexes obtained

This disclosure describes a method for preparing stable cell targeting conjugates. A further aspect of this disclosure relates to the stable cell targeting conjugates obtainable by the method and to pharmaceutical compositions comprising these stable cell targeting conjugates. A last aspect of this disclosure relates to the use of these conjugates and pharmaceutical compositions as a medicament.

Method for removing weakly bound functional moieties from cell targeting conjugates

The invention relates to a method for identifying a Mycobacterium species responsible for a mycobacterial infection in human or animal, comprising selecting a suitable mycobacterial species and strain; preparing at least one mycobacterial antigen, respectively antigen preparation; binding the antigen, respectively the antigen preparation to a suitable carrier; causing the binding antigen to react with antibodies from serum of an individual infected with a Mycobacterium species; making visible antigen-antibody reactions for a suitable antibody (sub-)class; and identifying the responsible Mycobacterium species on the basis of the reactions which are made visible. The invention further provides a diagnostic kit which takes the form of a dip-stick on which is arranged a carrier strip with mycobacterial antigens binding thereto, and means for visualizing antigen-antibody reactions occurring on the carrier after contact with the serum for testing. In another embodiment the diagnostic kit comprises a microtiter plate, in the wells of which a specified antibody is arranged, and means for making visible antigen-antibody reactions occurring in the wells after contact with the serum for testing. The third embodiment is an immunoblot with mycobacterial antigens separated by electrophoresis binding thereto, and means for visualizing antigen-antibody reactions occurring on the immunoblot after contact with the serum for testing.

Method and device for identifying a mycobacterium species responsible for a mycobacterial infection

The invention provides platinum-based probe compounds having the structure: ##STR1## wherein: Pt is a platinum atom, PROBE is a probe biomolecule for associating to a target biomolecule, M is a detectable marker moiety, and X and Y are stabilizing substituents. Also provided are platinum-based labeling compounds having the structure: ##STR2## wherein: Pt is a platinum atom, M is a detectable marker moiety, A is a displaceable leaving group, and X and Y are stabilizing substituents. The invention further provides platinum-based linker compounds having the structure: ##STR3## wherein: Pt is a platinum atom, A and B are the same or different reactive moieties, and X and Y are stabilizing substituents. Other Pt.sup.II and Pt.sup.IV compounds are also provided. Moreover, the invention provides methods for the preparation and use of these compounds, as well as diagnostic kits which contain the compounds.

Platinum-containing compounds methods for their preparation and

Platinum-containing compounds, methods for their preparation and

Method and device for identifying a mycobacterium species responsible

Growing community of inventors

Amsterdam, Netherlands

Hendrik Jan Houthoff