Apeptico Forschung Und Entwicklung Gmbh

Hendrik Fischer

Bernhard Fischer

Rudolf Lucas

Susan Jane Tzotzos

Helmut Pietschmann

A method of conditioning/improving lung functions extracorporeally by treatment of a non-ischemic donor lung ex vivo with a cyclized compound of the amino acid sequence of formulaX-GQRETPEGAEAKPWY-X  I

Pharmaceutical composition comprising a cyclic peptide of formula X1-GQRETPEGAEAKPWY-X2 and use for extracorporeal lung treatment

Described is a composition comprising a peptide which consists of 7-17 adjacent amino acids and comprises the hexamer TXEXXE, where X, X, and Xcan be any natural or non-natural amino acid, and the peptide is cyclized and does not exhibit TNF receptor binding activity, and an inhibitor of viral neuraminidase.

Composition comprising a peptide and an inhibitor of viral neuraminidase

Described is a composition comprising&#x2014;a peptide which consists of 7-17 adjacent amino acids and comprises the hexamer TXEXXE, where X, Xand Xcan be any natural or non-natural amino acid, and the peptide is cyclized and does not exhibit TNF receptor binding activity, and&#x2014;an inhibitor of viral neuraminidase.

What is described is a peptide which consists of 7-20, especially 7-17, adjacent amino acids and comprises the hexamer TXEXXE where X, Xand Xmay be any natural or unnatural amino acid, where the peptide does not have any TNF receptor binding activity and is cyclized, for use for the treatment and avoidance of the pulmonary form of altitude sickness.

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Vienna, Austria

Hendrik Fischer