Akzo N.v.

Akzo Nobel N.v.

Hendrik De Nijs

Herman Vromans

Antonius Paulus Sam

Rudolf Johannes Joseph Groenewegen

A ring-shaped device for controlled release of hormonal compounds comprising a first compartment having a non-medicated core of ethylene-vinyl-acetate copolymer encircled by a steroid hormone loaded ethylene-vinyl-acetate copolymer middle layer and a non-medicated outer layer of ethylene-vinyl-acetate copolymer. The device also contains a second compartment having a core of ethylene-vinyl-acetate copolymer loaded with a steroid hormone and a non-medicated outer layer of ethylene-vinyl-acetate copolymer.

Ring-shaped devices

The invention relates to an implant of polymeric material which can release a contraceptive agent for a relatively long time when fitted subcutaneously or locally.

Method of contraception

Contraceptive implant

The invention relates to an implant of polymeric material which can release a contraceptive agent for a relatively long time when fitted subcutaneously or locally. The implant comprises a core material of ethylene/vinyl acetate copolymer which functions as a matrix for a contraceptive substance, an ethylene/vinyl acetate membrane encasing the core material, and a contact layer at the interface of the core material and membrane which prevents the separation of the core material from the membrane. The implant of the invention is made by a co-extrusion process.

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Oss, Netherlands

Hendrik De Nijs