Tel Aviv University

Hemda Baabur-Cohen

Ronit Satchi-Fainaro

Ela Markovsky

Doron Shabat

Yana Epshtein

Shiran Ferber

Orit Redy-Keisar

Rachel Blau

Einat Kisin-Finfer

Polymeric systems useful for theranostic applications are disclosed. The polymeric systems comprise a fluorescent or fluorogenic moiety and a therapeutically active agent, each attached to the same or different polymeric moiety. The polymeric systems are designed such that a fluorescent signal is generated in response to a chemical event, preferably upon contacting an analyte (e.g., an enzyme) that is over-expressed in a diseased tissue or organ. Probes useful for inclusion in such polymeric systems, processes of preparing such probes and the polymeric systems, and uses thereof in diagnostic and/or theranostic applications are also disclosed.

Polymeric systems and uses thereof in theranostic applications

Polymeric conjugates of a polymeric backbone formed of a plurality of backbone units and having attached to portions of the backbone units two or more therapeutically active agents, or one or more therapeutically active agents and a NCAM targeting moiety, are disclosed. Uses of such polymeric conjugates in treating and/or monitoring cancer and/or medical conditions associated with angiogenesis are also disclosed.

Polymers having therapeutically active agents conjugated thereto, processes of preparing same and uses thereof

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Tel Aviv, Israel

Hemda Baabur-Cohen