Northwestern University

Northshore University Healthsystem

Avi Biopharma, Inc.

Unicorn Therapeutics, LLC

Hemant Kumar Roy

Vadim Backman

Hariharan Subramanian

Dhwanil Damania

Dhananjay Kunte

Mart Angelo De La Cruz

Yang Liu

Young L Kim

Vladimir Turzhitsky

Jeremy D Rogers

Patrick L Iversen

Richard Keith Bestwick

Michael Siegel

Brand Randall

Michael Goldberg

Randall Brand

Prabhakar Pradhan

Ramesh Wali

Disclosed are compositions comprising myokines and their methods of preparation and use. The disclosed myokine compositions and methods may comprise myokines having a molecular weight of greater than about 10 kDa such as myostatin and metrnl. The disclosed myokine compositions and methods may be utilized for treating and/or preventing cell proliferative and metabolic diseases and disorders. In particular, the disclosed myokine compositions and methods may be utilized for treating and/or preventing cell proliferative and metabolic diseases and disorders, such as cancer, and metabolic diseases and disorders, such as diabetes, non-alcoholic fatty liver disease, and heart disease.

Myokines for treating cell proliferative and metabolic diseases and disorders

Kits comprising myokines and platinum-based chemotherapeutic agents for treating colorectal cancer

The present disclosure provides methods for generating myokines in vitro and compositions comprising myokines. Such compositions may be used for treatment of diseases such as cancer and fatty liver disease.

Method of treatment of breast or colon cancer by administering muscle stimulated myokines

The present invention relates to detection of cancer, or assessment of risk of development thereof. In particular, the present invention provides compositions and methods detection of field carcinogenesis by identification of ultrastructural and molecular markers in a subject.

Cancer screening by detection of ultrastructural and molecular markers

The present invention, in one aspect, relates to a method for distinguishing between possible adenomatous and hyperplastic polyps using what is referred to as 'Early Increase in microvascular Blood Supply' (EIBS) that exists in tissues that are close to, but are not themselves, the abnormal tissue.

Method of using the detection of early increase in microvascular blood content to distinguish between adenomatous and hyperplastic polyps

Systems, methods, and apparatuses of elastic light scattering spectroscopy and low-coherence enhanced backscattering spectroscopy are described here. An apparatus couple-able to a light source and a target object, to facilitate light transmission between the light source and the target object, the apparatus comprises: a probe to emit incident light that is partially coherent obtained from the light source onto the target object and to receive interacted light, the interacted light to be backscattered light from illumination of the incident light on the target object, the probe comprising: a delivery channel having at least one delivery optical fiber with a distal end portion couple-able to the light source and a proximal end portion suited to couple the incident light to the target object, a collection channel having a first collection optical fiber suited to collect substantially co-polarized backscattered light and a second collection optical fiber suited to collect substantially cross-polarized backscattered light.

Systems, methods and apparatuses of elastic light scattering spectroscopy and low coherence enhanced backscattering spectroscopy

Systems and methods for identifying refractive-index fluctuations of a target are described in this application. One embodiment includes identifying one or more properties of emergent light, the emergent light to be emergent from a target, and determining refractive-index fluctuations of the target based on the one or more properties of the emergent light. The determining refractive-index fluctuations further comprises determining one or more of the variance of the refractive-index fluctuations and the spatial correlation length of the refractive-index fluctuations. The determining refractive-index fluctuations further comprises determining one or more of the variance of the refractive-index fluctuations and the spatial correlation length of the refractive-index fluctuations.

Method for identifying refractive-index fluctuations of a target

Systems, methods, and apparatuses of low-coherence enhanced backscattering spectroscopy are described within this application. One embodiment includes providing incident light comprising at least one spectral component having low coherence, wherein the incident light is to be illuminated on a target object in vivo. An intensity of one or more of at least one spectral component and at least one angular component of backscattering angle of backscattered light is recorded, wherein the backscattered light is to be backscattered from illumination of the incident light on the target object and wherein the backscattering angle is an angle between incident light propagation direction and backscattered light propagation direction. The intensity of the at least one spectral component and the at least one backscattering angle of backscattered light is analyzed, to obtain one or more optical markers of the backscattered light, toward evaluating said properties.

Systems, methods, and apparatuses of low-coherence enhanced backscattering spectroscopy

A method and composition for treating colorectal cancer is disclosed. The method involves administering to a subject, a therapeutically effective amount of a morpholino antisense compound (i) having a nuclease-resistant backbone, (ii) capable of uptake by target cancer cells in the subject, (iii) containing between 10-40 nucleotide bases, and (iv) having a base sequence effective to hybridize to a region of processed or preprocessed human SNAIL RNA transcript.

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Chestnut Hill, MA, United States of America

Hemant Kumar Roy