Bristol-myers Squibb Compnay

Hemanshu S Shah

Bhiku Patel

Jonas C Wang

Stacley Au

Cheng-Der Yu

Cheng Der Yu

Mark A Tepper

Susan Genier

John Gibson

A method and system is described for the noninvasive administration of a therapeutic concentration of a deoxyspergualin compound to a patient comprising iontophoretically passing the deoxyspergualin compound through an area of the skin of the patient at a flux effective to provide the therapeutic concentration.

Iontophoretic transdermal delivery of deoxyspergualin compounds

A gel formulation for topical administration with enhanced skin penetration properties comprising a therapeutically effective amount of an imidazole antifungal agent, either by itself or in combination with a steroid anti-inflammatory agent, in a vehicle system that includes lauryl alcohol is disclosed.

Lauryl alcohol as skin penetration enhancer for topical imidazole agents

The certain imidazoles have been found to exhibit anti-inflammatory as well as antifungal activity.

Topical anti-fungal agents having anti-inflammatory activity

Stable anhydrous gel formulations for topical antifungal use contain an imidazole, a steroid, a co-solvent system comprising monohydric and dihydric alcohols, and a hydroxyalkylcellulose gellant.

Antifungal gel formulations

An antifungal gel composition, effective at 0.2-2.0% by weight of an imidazole antifungal agent and 0.01-2.5% by weight of a 17-ester corticosteroid antiinflammatory agent, is provided for topical administration. This composition is highly effective in treating fungal infections and is capable of being stored without refrigeration for long periods of time without losing therapeutic effectiveness and while maintaining the uniformity and stability of the gel.

Growing community of inventors

Amherst, NY, United States of America

Hemanshu S Shah