Galapagos Genomics N.v.

Introgene B.v.

Helmuth Van Es

Abraham Bout

Ronald Vogels

Govert Johan Schouten

Stefan Frederik Franciscus Verlinden

Menzo Jans Emco Havenga

Novel means and methods for their use are provided to determine the function of the product(s) of one or more sample nucleic acids. The sample nucleic acids are synthetic oligonucleotides, DNA, or cDNA and encode polypeptides, antisense nucleic acids, or GSEs. The sample nucleic acids are expressed in a host by a vehicle to alter at least one phenotype of the host. The altered phenotype(s) is/are identified as a means to assign a biological function to the product(s) encoded by the sample nucleic acid(s).

High throughput screening of gene function using libraries for functional genomics applications

The invention relates to the targeted delivery of substances to cells. The invention provides a virus-like particle or gene delivery vehicle provided with a ligand capable of binding to a human amino acid transporter. Provided are, for example, ligands that can bind to the human transporter of cationic L-amino acids (hCAT1). Such hCAT1 binding molecules find applications in the design of vector systems for entry into human or primate cells. Preferred are retroviral envelope molecules, which&mdash;when incorporated in a virus particle&mdash;can infect hCAT1 positive cells at high frequencies. Also disclosed are methods for the design of such hCAT1 binding molecules.

Targeted delivery through a cationic amino acid transporter

High throughput screening of gene function using adenoviral libraries for functional genomics applications

Growing community of inventors

Hoofddorp, Netherlands

Helmuth Van Es