Basf Se Corporation

Basf Aktiengesellschaft

Helmut Zech

Michael Keil

Joachim Gebhardt

Michael Rack

Frederik Menges

David Cortes

Rodney F Klima

Robert Leicht

Jochen Schroeder

Jochen Schröder

Roland Goetz

Thomas Schmidt

Daniel Saelinger

Jan Hendrik Wevers

Stefan Orsten

Philip Muelheims

Sandra Loehr

Rudolf Haeberle

Tony Yegerlehner

The present invention relates to a process for preparing 4-chlorobenzyl propargylether comprising a step (a) of reacting 4-chlorobenzyl chloride with propargyl alcohol in the presence of a base and a phase transfer catalyst, wherein the reaction mixture comprises at least two phases, wherein one phase is an organic phase and one phase is an aqueous phase.

Process for preparing 4-chlorobenzyl propargyl ether

A process for manufacturing 5-chloromethyl-2,3-pyridine dicarboxylic acid anhydrides (I)   Compounds (I) are useful intermediates in the synthesis of herbicidal imidazolinones.

Process for manufacturing 5-chloromethyl-2,3-pyridine dicarboxylic acid anhydrides

A process for manufacturing 5,6-disubstituted-3-pyridylmethyl ammonium bromides (I), wherein wherein the symbols have the meaning given in formula (I), with bromine in the presence of a radical initiator in a solvent mixture comprising an aqueous phase and an organic phase, where the organic phase comprises a solvent selected from 1,2-dichloroethane, chlorobenzene, 1,2-dichlorobenzene, 1,3-dichlorobenzene, 1,4-dichlorobenzene and tetrachloromethane, and where the pH-value of the aqueous phase is from 3 to &#x3c;8, to obtain a 3-bromomethyl-5,6-disubstituted pyridine compound (III), wherein Y, Y, Z and Zhave the meanings given in formula (I), and

Process for manufacturing substituted 3-pyridylmethyl ammonium bromides

A process for manufacturing a 5-formyl-pyridine-2,3-dicarboxylic acid ester (I) wherein Z is hydrogen or halogen; Zis hydrogen, halogen, cyano or nitro and R, Rare independently C-C-alkyl, comprising the steps of (i) reacting a compound of formula (II), wherein the symbols are as in formula (I), with a nitrosation agent (III) R&#x2014;O&#x2014;N&#x2550;O (III) wherein Ris C-C-alkyl, in the presence of an alkali metal or alkaline earth metal alcoholates or carbonates in a polar aprotic solvent at a temperature of from &#x2212;45 to 40&#xb0; C., to obtain an oxime compound (IV) where Z, Z, Rand Rare as in formula (I), and (ii) reacting oxime compound (IV) with an aliphatic C-C-aldehyde in the presence of a Lewis acid at a temperature in the range of from 0 to 100&#xb0; C. The compounds of formula (I) are useful intermediates in the synthesis of herbicidal imidazolinones, like imazamox. 

Process for manufacturing 5-formyl-pyridine-2,3-dicarboxylic acid esters

2-[(1-cyanopropyl)carbamoyl]-5-chloromethyl nicotinic acids of formula (I) where Z is hydrogen or halogen; Zis hydrogen, halogen, cyano or nitro; Ris C-Calkyl; Ris C-Calkyl, C-Ccycloalkyl or Rand R, when taken together with the atom to which they are attached, represent a C-Ccycloalkyl group optionally substituted with methyl, and Ris hydrogen or a cation preferably selected from the group consisting of alkali metals, alkaline earth metals, manganese, copper, iron, zinc, cobalt, lead, silver, nickel, ammonium and organic ammonium; are useful intermediates for the synthesis of herbicidal imidazolinones. 

2-[1-cyanopropyl)carbamoyl]-5-chloromethyl nicotinic acids and the use thereof in manufacturing herbicidal imidazolinones

The present invention relates to a process for preparing 1-alkyl-3-phenyluracils of the formula I  

Method for production of 1-alkyl-3-phenyluracils

Growing community of inventors

Bad Duerkheim, Germany

Helmut Zech