Nmi Naturwissenschaftliches Und Medizinisches Institut an Der Universitaet Tuebingen

Tetec Tissue Engineering Technologies Ag

Cellendes Gmbh

Nmi Naturwissenschaftliches Und Medizinisches Institut an Der Universitat Tubingen

Nmi Naturwissenschaftliches Und Medizinisches Institut an Der Universität Tübingen in Reutlingen Stiftung Bürgerlichen Rechts

Helmut Wurst

Karin Benz

Jürgen Mollenhauer

Juergen Mollenhauer

Nils Clausen

Karima Larbi

Markus Herrmann

Nina Baldassi

Barbara Platz

Reinout Stoop

Brigitte Angres

Nadine Rischert

Reinout Stoop Stoop

A combination comprising, spatially separate from one another, a first component and a second component, where the first component comprises crosslinkable albumin and the second component comprises a polymer, wherein non-terminal monomer units of the polymer comprise at least partially, more particularly only partially, an albumin-crosslinking group. Additionally disclosed is a reaction product obtainable by means of the combination, to a medical device, to a medicinal product for innovative therapies, to a kit, to a discharge apparatus, and to a functionalized hyaluronic acid.

Combination with albumin, in particular for treating a cartilage defect

The invention relates to an injectable biocompatible composition based on a polymeric support as well as to a method for producing it, which composition which comprises at least one hydrophilic polymer, wherein the polymer is polymerizable in situ to form a gel, and wherein the hydrophilic polymer is crosslinkable serum albumin or crosslinkable serum protein. The composition can be used in the restoration, the reconstruction, and/or the replacement of tissues and/or organs, or as a drug release implant in mammals. The composition is particularly suitable for treating cartilage disorders of a diseased or injured articular site in a mammal.

Injectable biocompatible composition

The present invention relates to a biomaterial for cell or tissue culture, based on a polymeric carrier, which contains at least one crosslinkable hydrophilic polymer. The polymer is functionalized with groups that are selected from maleimide, vinylsulfonic, acrylate, alkyl halide, azirine, pyridyl, thionitrobenzene acid groups, or arylating groups. The invention relates further to a method of production of said biomaterial, and the use of particular functionalizing groups for the production of a biomaterial for the cultivation of tissue and/or cells. The biomaterial can have biofactors that exert a particular action on cells.

Biomaterial based on a hydrophilic polymeric carrier

A peptide cross-linking agent in the form of a linear molecule has a molecular mass of 3 to approximately 60 kDa. The peptide cross-linking agents are used for cross-linking functionalized polymers to form hydrogels having two or more components.

Cross-linking agents for hydrogels that contain cleavable peptides and short-chain polymers

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Pfullingen, Germany

Helmut Wurst