Arzneimittelwerk Dresden Gmbh

Helmut Wunderlich

Dieter Lohmann

Hildegard Poppe

Reni Bartsch

Natalja V Kaverina

Valentin V Lyskovzev

Aleksandr P Skoldinov

Andreas Stark

Lothar Zenker

Anna N Grizenko

Angelika Rostock

Christine Siegemund

Tatjana A Voronina

Oleg M Glozman

Larisa M Mescerjakova

Taisija L Garibova

Sergej B Seredenin

Ljudmila A Zmurenko

Lothar Zenkar

Grigorij G Rozancev

Ekaterina K Grigoreva

Artur V Valdman

Ilmira C Rachmankulova

The invention is directed to N-acetyl-4-phenyl-pyrrolidin-2-ones, which, because of their pronounced cerebroprotective effect in human medicine, can be used for the prophylaxis and treatment of cerebral functional disorders. Pursuant to the invention, these compounds are synthesized by reacting 4-phenyl-pyrrolidin-2-ones with a reactive derivative of a carboxylic acid, or by cyclizing N-acylaminobutyric acid derivatives.

N-acyl-4-phenyl-pyrrolidin-2-ones and method for preparing

New 3-carbalkoxyamino-5-(alpha-aminopropionyl)-5H-dibenz[b,f]azepines of formula I and their pharmaceutically acceptable salts were found to be suitable actives for the treatment of cardiac arrhythmia. Previously unknown 3-carbalkoxyamino-5-(alpha-halogenpropionyl)-5H-dibenz[b,f]azepines are obtained from 3-carbalkoxyamino-5H-dibenz[b,f]azepines by reaction with alpha-halogenpropionyl halides. Through their reaction with ammonia, primary amines or secondary amines, the new 3-carbalkoxyamino-5-(alpha-aminopropionyl)-5H-dibenz[b,f]azepines are obtained, which can be optionally converted into their pharmaceutically acceptable acid addition salts.

3-carbalkoxyamino-5-(alpha-aminopropionyl)-5H-dibenz[b,f]azepines and

New 3-carbalkoxyamino-5-aminoacyl-5H-dibenz[b,f]azepines and their pharmaceutically acceptable acid addition salts, and methods for their synthesis are described. These compounds are useful as antiarrhythmic agents in the treatment of heart disorders. The new compounds are made by reacting a 3-carbalkoxyamino-5-halogenacyl-5H-dibenz[b,f]azepines with an amine to form the desired target product, which can be optionally converted into its pharmaceutically acceptable acid addition salt.

3-carbalkoxyamino-5-aminoacyl-5H-dibenz[b,f]azepines, and methods for

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Dresden, Germany

Helmut Wunderlich