Hoffmann-la Roche Inc.

Roche Palo Alto LLC

Basf Aktiengesellschaft

Helmut Werner Stahr

Ursula Hoffmann

Michelangelo Scalone

Reinhard Reents

Michael Jansen

Hans Hilpert

Mark Rogers-Evans

Pius Waldmeier

Fabienne Hoffmann-Emery

Shaoning Wang

Tim Sattelkau

Goesta Rimmler

Bernd Sch&auml;fer

Dennis A Smith

Wolfgang Goehring

Simone Schleich

Uli Kazmaier

G&uuml;nter Helmchen

Volker Wolfart

Gerard John Harnett

Francois Gantz

A process for the preparation of a compound of formula (Ia): which are useful as intermediates in the preparation of i.a. pharmaceutically active compounds.

Preparation for a cyclohexanecarboxylic acid derivative and intermediates

The present invention relates to a new process for the preparation of macrocyclic HCV protease inhibitor compounds of the formula wherein Ris an amino protecting group and X is halogen by way of a ring closing metathesis approach.

Process for the preparation of a macrocycle

A process for the preparation of a compound of formula (I): which are useful as intermediates in the preparation of i.a. pharmaceutically active compounds.

Process for cyclohexanecarboxylic acid derivatives

The present invention relates to a new process for the preparation of tripeptides of formula I wherein Ris an amino protecting group and X is a halogen atom and wherein the tipeptide contains two olefinic moieties suitably disposed to undergo an intramolecular olefin metathesis reaction and produce macrocyclic tripeptides useful for the manufacture of macrocyclic HCV protease inhibitors.

Process for the preparation of macrocyclic compounds

A novel process for the preparation of compounds of formula I and optionally converting a compound of formula I into a pharmaceutically acceptable salt is disclosed. The compounds of formula I and the corresponding salts, e.g. the sodium salts, are pharmaceutically active substances. Processes for the creation of intermediates are also disclosed.

Process for the preparation of the insulin sensitizer

Method of producing 3,4-dehydroprolines and 3,4-dehydropiperidines

A process is described for preparing certain 4-alkyl- or 4-aryl-pyridine derivatives.

Process for the preparation of pyridine derivatives

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Lörrach, Germany

Helmut Werner Stahr