Hoffmann-la Roche Inc.

Cyclenium Pharma Inc.

F. Hoffmann-la Roche Ag

Tranzyme Pharma Inc.

Helmut Thomas

Amal Wahhab

Dwight MacDonald

Hans Hilpert

Hong Shen

Theodor Stoll

Bernhard Fasching

Carsten Kroll

Adrian Schaeublin

Claudia Zampaloni

Julien Beignet

Stephen Jackson

Sabine Kolczewski

Konrad H Bleicher

Alexander Alanine

Taishan Hu

Mark L Peterson

Daniel Dubé

Luc Richard

Konrad Bleicher

Dwight Macdonald

Daniel Dube

Alain Rouillard

The present invention provides compounds of formula (I)

Peptide macrocycles against

The present invention provides compounds of formula (I) 

Peptide macrocycles against Acinetobacter baumannii

The present disclosure relates to novel macrocyclic compounds and libraries thereof containing heteroaryl moieties that are useful as research tools for drug discovery efforts. The present disclosure also relates to methods of preparing these compounds and libraries and methods of using these libraries, such as in high throughput screening. In particular, these libraries are useful for evaluation of bioactivity at existing and newly identified pharmacologically relevant targets, including G protein-coupled receptors, nuclear receptors, enzymes, ion channels, transporters, transcription factors, protein-protein interactions and nucleic acid-protein interactions. As such, these libraries can be applied to the search for new pharmaceutical agents for the treatment and prevention of a range of medical conditions.

Libraries of heteroaryl-containing macrocyclic compounds and methods of making and using the same

Peptide macrocycles against acinetobacter baumannii

Growing community of inventors

Sherbrooke, Canada

Helmut Thomas