Hoechst Aktiengesellschaft

Dade Behring Marburg Gmbh

Helmut Strecker, Deceased

Hans Wissmann

Guido Simons

Peter Molz

Gerd Schnorr

Heinz Jurgen Skrzipczyk

Dietrich Brocks

Rupert Timpl

Volkmar Gunzler-Pukall

Henning Hachmann

Jurgen Punter

A method for determining the concentration of the free fraction of an active compound, present in a biological fluid, in the presence of natural binders, the free and bound fractions of the active compound being in mutual equilibrium, by

Process and test kit for determining free active compounds in biological

It is possible with the aid of a monoclonal antibody which is specifically directed against an epitope of amino-terminal procollagen peptide (type III) which is not present on the fragment Col 1, and of a second monoclonal or polyclonal antibody against an epitope of amino-terminal procollagen peptide (type III), to determine said peptide with great accuracy. It is also, possible, with the aid of a monoclonal antibody which is specifically directed against an epitope of amino-terminal procollagen peptide (type III) which is not present in Col 1, to determine with great accuracy said procollagen peptide in body fluids.

Monoclonal antibodies for the selective immunological determination of

The invention relates to novel thyronine derivatives of the formula ##STR1## in which n is 10-400, R denotes H, alkyl or N-carbonylthyronine, R.sup.1 and R.sup.2 are identical or different and denote hydrogen or iodine, and R.sup.3 denotes H or alkyl, a process for the preparation of the compounds, and their use when carrying out immunoassays.

Novel thyronine derivatives

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Pfungstadt, Germany

Helmut Strecker, Deceased