Hoechst Aktiengesellschaft

Helmut Strecker

Gerhard Kloss

Dietrich Brocks

Hans Wissmann

Rupert Timpl

Guido Simons

Michael Molter

Henning Hachmann

Eberhard Schickel

Horst Neubauer

Reinhard Kasmarker

The invention relates to new thyronine derivatives of the formula ##STR1## in which n is 1-6, R denotes hydroxyl, alkyl or aryl, R.sup.1 and R.sup.2 are identical or different and denote iodine or hydrogen, and R.sup.3 denotes hydrogen, alkyl or aralkyl, a process for the preparation thereof, and the use thereof for carrying out radioimmunoassays.

Thyronine derivatives

The antigens procollagen peptide (type (III) and procollagen peptide col 1 (type III) can be determined together immunologically by either

Procedure for immunologic determination of procollagen peptide (type

A process is disclosed for the preparation of a diagnositc agent for scanning the RES, in particular the liver, by mixing the sodium salt of 1-phenyl-2,3-dimethyl-pyrazolone-4-methylamino-methylsulfonic acid or 1-phenyl-2,3-dimethyl-pyrazolone in aqueous solution with tin(II) salt, adjusting the solution to a pH between 4 and 9, optionally lyophilizing the mixture and adding .sup.99m Tc-pertechnetate in physiological saline solution.

Technetium-labelled diagnostic agent for the examination of the RES

Nuclide generators for preparing sterile and pyrogen-free radioactive solutions consist of a generator column which is provided with radiation shielding and connected to a container for eluting agent and has a connection to a container for eluate. The generator and the container for eluting agent are located in vessels with centering devices, wherein the generator column with its radiation shielding is located in a fixed position relative to the vessel between two centering devices and connected via a cannula to the container for eluting agent which is held in a recess of one centering device in a fixed position relative to the generator column. The other centering device has also a recess for guiding and holding the eluate container which is connected to the generator column via a cannula.

Nuclide generator for preparing radio-nuclides

A diagnostic agent for the visualization of the kidneys is disclosed as well as a process for its manufacture. The new agent consists of pyrrolidinomethyl-tetracycline in a buffer solution, a tin(II) salt and technetium-99m in physiological sodium chloride solution.

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Seeheim, Germany

Helmut Strecker