Roche Diagnostics Operations, Inc.

Roche Diagnostics Gmbh

F. Hoffmann-La Roche Ag

Helmut Rinne

Gregor Ocvirk

Arnulf Staib

Uwe Wittmann

Ralf Gessler

Hans-Joerg Pfleiderer

The invention generally relates to a sensor system. In particular to a sensor for glucose monitoring. The invention also also relates to an arrangement and a method for monitoring a constituent and in particular glucose in body tissue using a sensor system.

Analyte monitoring sensor system for monitoring a constituent in body tissue

Sensor system as well as an arrangement and method for monitoring a constituent and in particular glucose in body tissue

The invention relates to a method for monitoring an arrangement for determining a concentration of an analyte in a body fluid. The determination of the concentration of the analyte by means of the arrangement involves a procedure in which the analyte from the body fluid passes through an interface and is transported in a stream of liquid into a flowmeter chamber, in which a measurement is carried out to determine the concentration of the analyte. The evaluation of the measurement takes place in a signal processor. The monitoring of the arrangement comprises the following steps: measurement of measured values of at least two correlated system parameters of the arrangement by means of a sensor system, and comparison of the measured values with limit values stored for each of the system parameters in a storage unit, to obtain a combination of at least two comparison results.

Method for monitoring an arrangement for determining the concentration of an analyte in a body fluid

The invention concerns an array and a method for dosing a hormone regulating the blood glucose, especially insulin, of a diabetic patient. In order to improve the administration of the hormone, the invention provides the following characteristic combination: a first sensor for measuring tissue glucose level; a controller having as an input the measured tissue glucose level from the first sensor, the controller having a control algorithm to determine an amount of hormone to be dosed based upon the measured tissue glucose level; a hormone dosing unit connected to the controller and automatically administering a hormone dose based upon a signal received from the controller; a second sensor for measuring an influencing patient variable; a pilot control device connected to the second sensor, the pilot control device connected to and forming a circuit with the controller, the pilot control device acting on the controller in accordance with the influencing patient variable that is measured by the second sensor, whereby the pilot control device reduces dead time of the controller.

Array and method for dosing a hormone regulating blood sugar in a patient

The invention concerns an array and a method for dosing a hormone regulating the blood glucose, especially insulin of a diabetic patient (). In order to improve the administration of the hormone, the invention provides the following characteristic combination: a) a measuring device () to detect measured values correlatable with blood sugar; b) a controlling means () comprising a controller () and a hormone dosing device () for supplying a hormone dosage; c) a pilot control device () acting on the hormone fine dosage controlling means () for performing a coarse pre-control in accordance with at least one influence variable that influences blood glucose.

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Hamburg, Germany

Helmut Rinne