Avl Ag

Roche Diagnostics Operations, Inc.

Avl Medical Instruments Ag

F. Hoffmann-la Roche Ag

Avl Gesellschaft Fur Verbrennungskraftmaschinen Und Messtechnik M.b.h.

Avl Medical Instruments

Erba Technologies Austria Gmbh

Roche Diagnostics Gmbh

Helmut Offenbacher

Herbert Kroneis

Otto S Wolfbeis

Christoph Ritter

Bernhard Schaffar

Massoud Ghahramani

Hermann J Marsoner

Erich Kleinhappl

Hellfried Karpf

Heinz Kontschieder

Wolfgang Huber

Andreas Martin Dolezal

Marco Jean Pierre Leiner

Johann Harer

Marie-Luise Schinnerl

Erna Schwarzenegger

Ewald Jobstl

Bernhard Peter Harald Schaffar

Gabriela Pestitschek

Nicole Wiedner

Werner Sallegger

Stefan Köstler

Claudia-Gemma Muresanu

Gregor Steiner

Franz-Josef Krysl

Marco Jean-Pierre Leiner

Franz Josef Krysl

In a reference electrode for the potentiometric measurement of ion concentrations, comprising a swellable polymer body filled with at least one electrolyte salt and a potential sensing element of the second type located in the polymer body, preferably of the Ag/AgCl type, the polymer body is composed of preferably organic, hydrophobic prepolymer segments, which are three-dimensionally crosslinked by preferably organic, hydrophilic polymer chains.

Reference electrode for the potentiometric measurement of ion concentrations

The present invention concerns an electrochemical sensor for determining oxygen dissolved in an aqueous measuring medium, a process for its production as well as a method for determining oxygen dissolved in an aqueous measuring medium using the electrochemical sensor.

Oxygen sensor with a microporous electrolyte layer and partially open cover membrane

The invention concerns a sensor cassette that can be inserted into an analyzer comprising a continuous measuring channel for receiving fluidic media and sensory elements for determining chemical and/or physical parameters of the fluidic media. According to the invention the sensor cassette consists of at least two permanently connected but separately manufactured modules which each have a housing and a measuring channel section wherein the measuring channel sections of adjacent modules are connected to the continuous measuring channel by a fluidic coupling and wherein at least one of the connected modules is designed as a sensor module and has a sensor array comprising at least two sensory elements. Furthermore, a memory element is allocated to the sensor cassette on which specific information for the sensor cassette in particular with regard to its construction from the respective modules is stored.

Modular sensor cassette

The present invention relates to electrochemical sensors for determining gaseous analytes in an aqueous measuring medium, to a process for producing such sensors, and to a process for determining gaseous analytes dissolved in an aqueous measuring medium using the electrochemical sensors. The electrolyte layer of the sensors comprises at least one particulate material and at least one binder which together form a porous, non-swellable framework structure, wherein the pores in this framework structure are configured to absorb a liquid electrolyte or contain the liquid electrolyte.

Gas sensor with a microporous electrolyte layer

In an electrode system, particularly for electrochemical sensors, which comprises a working electrode, a counterelectrode and an electrolyte, the counterelectrode is constituted by a material containing an elementary carbon, whereby the long-term stability of the electrode system is considerably increased (FIG. ).

Electrode system

A membrane for use in chloride-sensitive electrodes, comprises a polymer matrix with at least one electroactive component. The polymer matrix of the membrane contains an epoxy resin with an amino compound as a curing agent. For the purpose of reducing the danger of contamination and improving the useful life of the electrode, the epoxy resin is provided with at least one epoxy resin compatible flexibilizer, and the content of epoxy resin plus added flexibilizer in the electrode membrane amounts to more than 60% by weight, while that of the electroactive component is not more than 35% by weight, and preferably not more than 30% by weight.

Chloride-sensitive electrode membrane

The invention is concerned with a sensor for the determination of the concentration and the detection of an enzyme substrate in a liquid sample, the sensor comprising an enzyme capable of reacting with the enzyme substrate while producing a substance directly or indirectly detectable, a detection device for this substance and a cover membrane from a polymer permeable to the enzyme substrate, characterized in that the polymer is a polyvinyl chloride copolymer, i.e. a copolymer from vinyl chloride and a further monomer, the copolymer comprising hydrophilic groups. The sensor according to the invention may be provided as an optical sensor or as an amperometric sensor.

Sensor with PVC cover membrane

Biological components such as enzymes are immobilized in a three-dimensional cross-linked hydrophobic polymer. An enzyme is mixed with an aqueous solvent and a non-crosslinked prepolymer having an essentially nonpolar main chain with attached polar hydrophilic groups and cross-linking groups. The resultant mixture is exposed to cross-linking temperatures to react the prepolymer via the cross-linking groups without additional catalyst or cross-linking agents, and the aqueous solvent is evaporated to form a three-dimensional cross-linked hydrophobic polymer matrix containing the enzyme. The prepolymer can be an oil alkyl resin containing the main chain with attached polar hydrophilic groups and cross-linking groups. The oil alkyl resin is cross-linked by autoxidation, and aqueous solvent is evaporated to form the polymer matrix. A biosensor is prepared having the enzyme-containing polymer matrix on the surface of a supporting layer which contains cross-linking groups that improve adhesion between the supporting layer and the polymer matrix. Catalytic particles or charge conducting particles may be in the polymer matrix, and multiple polymer matrixes with different enzymes may be formed.

Preparation of a hydrophobic polymer matrix containing immobilized

In order to reduce the measuring volume in a device for measuring chemical and physical parameters of liquid or gaseous media by means of optical sensor elements whose optodes may be replaced easily, a measuring unit with a sample channel is provided which may be inserted into a supporting frame of the device and which may be connected to ingoing and outgoing sample lines via capillary bores. The measuring unit contains a sensor carrier forming the boundary of the sample channel on one side, which sensor carrier has bores holding the optodes. The indicator film of each individual optode is situated in the plane of the sensor carrier facing the sample channel.

Device for measuring chemical and physical parameters of a liquid or

In order to eliminate interferences of an optical or chemical nature, preferably in optical sensors, a cover layer is provided which comprises a hydrophilic, ion-permeable polymer membrane containing precious metal pigments deposited by a reduction or reduction/cementation technique for the purpose of suppressing straylight.

Cover layer for optical ion sensors

A sensor element useful in making fluorescence-optical measurements includes a substrate having a carrier surface, particles having a large specific surface are which are glued, melted or sintered onto the carrier surface so as to provide small elevations of a regular distribution on the carrier surface, and an indicator substance immobilized on the particles. Additional substances can be applied to the particles to reduce undesirable influences of properties of the sample on the indicator substance.

Method of making a sensor element for fluorescence-optical measurements

Bodies of borosilicate glass with a B.sub.2 O.sub.3 content of less than 13 percent by weight are provided with a microporous layer of a thickness of 5 to 20 .mu.m, and are thus turned into carriers for optical sensors. This process is characterized by the following steps. Thermal decomposition for 5 to 10 days at 500.degree. to 560.degree. C.; removal of the topmost layer of glass to a depth of at least 10 .mu.m in the part of the surface to be rendered porous; leaching of the separated borate phase with diluted mineral acids for a minimum of 2 days at 70.degree. to 98.degree. C.; and after-treatment of the microporous layer, including (a) chemical treatment with concentrated sulphuric acid and concentrated nitric acid for 2 hours at 20.degree. C., and (b) heat-treatment for 10 minutes to 2 hours at 450.degree. to 700.degree. C.

Method for preparing substrates for optical sensors

One measurement each is obtained from two optical sensors of ion concentration, following which the measured values are used for empirical determination of the ionic strength of an electrolytic solution. The sensors contain the same indicator substance but differ with regard to surface modification, thus ensuring different responses to ionic strength in spite of identical excitation and fluorescence wavelengths and the resulting simplicity of the optical system.

Method for determining ionic strength of a sample

An arrangement for the fluorescence-optical measurement of concentrations of substances contained in a sample includes a detector, a light source and a sensor element that includes a carrier element, the carrier element having an indicator layer on a portion thereof and an indicator-free surface, the carrier element being transparent to the radiation used, and having a refractive index which is greater than that of the ambient medium at the indicator-free surface, the light space being positioned such that the transmission of light from the light source to the indicator layer, and from there to the detector, is achieved, at least partially, by total reflection in the carrier element.

Arrangement for fluorescence-optical measurement of concentrations of

Fluorescence-optical indicator material is chemically bonded in a network structure permeating a carrier membrane of the sensor element. As this network structure is independent of the membrane and not chemically bonded thereto, the properties of the membrane and the indicator are not affected by the immobilization.

Growing community of inventors

Graz, Austria

Helmut Offenbacher