Bayer Aktiengesellschaft

Helmut Luchtenberg

Andreas Ohm

Roland Rupp

Manfred Bucheler

Takaaki Nishioka

Eduard Porges

Wolfgang Schmidt

Josef Schmoll

Wolfgang Opitz

Ahmed Hegasy

Klaus-Dieter Ramsch

Shinji Maegata

Bernd Streuff

Ulrich Tenter

Haruo Kanasaki

Heinrich Feltkamp

Kenji Kuratani

This invention provides a long-lasting release solid nifedipine preparation which exhibits clinically sufficient effect when administered once per day. A press coated tablet whose core and shell each contains nifedipine, the dissolution rate of nifedipine from said tablet being (a) in the dissolution test using a sinker according to method 2 of the dissolution test method as prescribed by the Pharmacopoeia of Japan, after 2 hours 10-40% after 4 hours 30-65% after 6 hours at least 55%, and (b) in the dissolution test according to the disintegration test method as prescribed by the Pharmacopoeia of Japan, after 3 hours 20-45% after 4 hours 30-65%.

Long-lasting release nifedipine preparation

A pharmaceutical formulation comprising by weight 30 to 95% of 1cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-quinoline-3-carb oxylic acid; 4.5 to 25% of a dry binder based on cellulose; 0 to 30% of a disintegration auxiliary based on starch; 0.5 to 10% of a disintegration auxiliary based on a cellulose derivative and/or a cross-linked polyvinyl-pyrrolidone; 0 to 2% of a flow-improving agent, and 0 to 3% of a lubricant. Tablets and capsules made from granules of the formulation, about 0.8 to 2 mm in size, exhibit high bioavailability and excellent storage stability.

Pharmaceutical formulations of ciprofloxacin

A solid, rapidly absorbable composition by weight consisting of 1 part by weight of nimodipine, 0.01 to 1.5 parts of polyvinylpyrrolidone with an average molecular weight of 15,000 to 50,000 and 1 to 12 parts by weight of crosslinked insoluble polyvinylpyrrolidone.

Solid composition containing dihydropyridine, PVP and PVPP

A solid medicament preparation having long-lasting action containing a sparingly soluble dihydropyridine active compound of the Formula (I) ##STR1## the preparation having a core-coating construction, the core containing at least one of the above mentioned dihydropyridines in slow-release form, the inner-most coating situated around the core contains no active compound and only dissolves slowly and adjacent to the inner-most coating a rapid release initial dose of the active compound mixed with a polymer.

DHP delayed release preparation

A pharmaceutical formulation tablet with a long-lasting action for 1 to 2 daily doses having a diameter between about 0.5 and 15 mm and comprising

Dihydropyridine depot formulation

The invention relates to solid pharmaceutical preparations which have a long-lasting action and are for dihydropyridines in the form of a press coated tablet, and a process for their preparation.

Press coated DHP tablets

In the treatment of cardiovascular and coronary disorders by administering to a patent suffering therefrom a solid preparation comprising nifedipine, the improvement which comprises administering such nifedipine in the form of a solid two-phase medicament formulation comprising a nifedipine coprecipitate, in which the nifedipine is present in a non-crystalline form, and crystalline nifedipine, whereby the nifedipine rapidly enters the blood stream in a relatively high concentration which is maintained for a relatively long time.

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Niederkassel, Germany

Helmut Luchtenberg