Roche Diagnostics Gmbh

Roche Diagnostics Operations, Inc.

Boehringer Mannheim Gmbh

F. Hoffmann-La Roche Ag

Helmut Leininger

Wolfgang-Reinhold Knappe

Detlef Thym

Peter Seelig

Franz Wittmann

Ralf Steinbrueck

Karl Miltner

Rolf Lerch

Gregor Bainczyk

Bruno Robert Thoes

Rolf Nagel

Udo Manser

Bernd Eisenbarth

Franz Bolduan

The invention concerns a diagnostic tape unit with a test tape that can be wound onto a spool which comprises a transport tape and a plurality of test elements mounted thereon, where the test elements have an analytical reagent layer, a carrier foil supporting the reagent layer and a piece of adhesive tape connecting the carrier foil with the transport tape, and where the front side of the reagent layer facing away from the carrier foil is designed for the application of a sample substance. According to the invention it is proposed that the test elements in combination with the light transmitting transport tape in each case form an optical multi-layer system for a rear-side reflection-photometric measurement of the reagent layer.

Diagnostic measuring system

Diagnostic tape unit

The invention relates to a packaging system for medical consumables, in particular test elements. The packaging system comprises an outer packaging, which accommodates a first desiccant supply, and a magazine with an unused test element supply. In the closed state of the outer packaging, the first desiccant supply of the outer packaging acts on the interior of the magazine via a connection that permits water vapor diffusion. In exemplary embodiments, the magazine includes a second desiccant supply. The communication of water vapor between the magazine and outer package reduces the load on the desiccant supply in the magazine.

Outer packaging system for medical consumables

A flat-shaped functional overlay for at least one region of a flat-shaped flexible object which does not form a fold when the sandwich composed of the flexible object and overlay is bent towards the side on which the overlay is located is described. The overlay is composed of one or several flat-shaped overlays which are attached to the flexible object in such a way that a part of their surface can move freely relative to the surface of the object covered by this part in the direction of curvature produced when the object is bent. In addition diagnostic test strips are described which have such an overlay.

Method of assembling a diagnostic test strip having a functional overlay

Functional overlay for flexible objects in particular for diagnostic test strips

The invention concerns a system for the storage and transport of sample material on absorbent material which is characterized in that the system contains no test reagents and it additionally includes a closable container containing a medium that can absorb moisture such as a desiccant in addition to the absorbent material for absorbing a liquid sample. Furthermore the system according to the invention can contain an agent to stabilize the sample material and optionally further auxiliary substances.

Storage and transport system for sample material

Analytical system for evaluating test elements having means of determining whether a sufficient amount of sample liquid was evenly applied to an application zone comprising in a first embodiment of the invention at least two sources of light which illuminate separate or at least not fully overlapping areas of the application zone or the evaluation zone of the test strip, a control unit with which the light sources, of which there at least two, can be independently activated, at least one sensor which detects light reflected by the evaluation zone or transmitted by the evaluation zone and supplies an output signal proportional to the intensity of light as well as an evaluation unit which receives a first output signal from the sensor and converts it into a first measured value when the first of the light sources is activated, receives a second output signal from the sensor and converts it into a second measured value when the second of the light sources, is activated and compares the measured values and determines whether the deviation of the first value measured from the second value measured is sufficiently small. In a second embodiment of an analytical system according to the invention, at least one light source is used to illuminate the sample application zone or the evaluation zone of a test element and at least two sensors detect light reflected or transmitted by the evaluation zone, the output signal of the sensors being converted into measured values by the evaluation unit which determines whether the deviation of the measured values is sufficiently small.

Analytical system with means for detecting too small sample volumes

The invention concerns a diagnostic test carrier (1) containing a supporting layer (2) with a detection layer (3) arranged thereon containing the reagents required to determine an analyte in a liquid sample and a network (4) covering the detection layer (3) which is larger than the detection layer (3) and which is attached to the supporting layer (2), wherein the network (4) is a plied knitted fabric the threads of which are highly roughened on the side facing the detection layer (3) whereas the threads on the side of the knitted fabric which face away from the detection layer (3) are relatively smooth as well as the use of such a test carrier to determine an analyte in a liquid and the use of such a knitted fabric as a layer spreading liquid in a diagnostic test carrier. Moreover the invention concerns a method for the determination of an analyte in a liquid sample with the aid of a test carrier according to the invention.

Diagnostic test carrier and methods in which it is used to determine an

The present invention concerns a diagnostic test carrier (1) containing a supporting layer (2) with a detection layer (3) arranged thereon containing the reagents required to determine analyte in a liquid sample and a network (4) covering the detection layer (3) which is larger than the detection layer (3) and which is attached to the supporting layer (2), which is characterized in that the network (4) is hydrophilic but not capillary active on its own and an inert cover (5) made of sample-impermeable material is arranged over the areas (6) of the network that extend beyond the detection layer in such a way that a sample application site (7) remains free on the region of the network (4) covering the detection layer as well as the use of such a test carrier for the determination of analyte in a liquid. In addition the invention concerns a method for the determination of an analyte in a liquid sample with the aid of a test carrier according to the invention.

Growing community of inventors

Mannheim, Germany

Helmut Leininger