Merck + Co., Inc.

Helmut Kropp

Frederick M Kahan

Ronald W Ratcliffe

Jeffrey N Clark

Daniel O Farrington

Robert R Wilkening

Robert D Wilkening

9a-Azalides, and pharmaceutical compositions containing them, are useful in the treatment and prevention of bacterial respiratory and enteric infections in livestock animals, particularly in cattle and swine.

9a-azalides as veterinary antimicrobial agents

8a-Azalides are useful in the treatment and prevention of bacterial respiratory and enteric infections in livestock animals, particularly in cattle and swine.

8a-azalides as veterinary antimicrobal agents

A combination of a carbapenem of the formula: ##STR1## where R is H or CH.sub.3 and R.sup.1 is ##STR2## with a renal dipeptidase inhibitor is disclosed.

Combination of 2-substituted carbapenems with dipeptidase inhibitors

A novel antibacterial drug combination is provided, one component being a 2-substituted penem, and the other component is a dipeptidase (E.C.3.4.13.11) inhibitor. The dual-component combination is formulated so that 1 to 3 parts by weight of the penem are employed for 30 to 1 parts by weight of the inhibitor compound.

Combination of thienamycin-type antibiotics with dipeptidase inhibitors

Use of substituted propenoates to prevent nephrotoxicity of certain

Antibacterial compositions of thienamycin-type compounds and a dipeptidase (E.C.3.4.13.11) inhibitor.

A novel antibacterial drug combination is provided, one component being a fused ring .beta.-lactam, such as thienamycin and its semi-synthetic derivatives, and the other component is a dipeptidase (E.C. 3.4.13.11) inhibitor. The dual-component combination is formulated so that 1 to 3 parts by weight of the .beta.-lactam compound are employed for 30 to 1 parts by weight of the inhibitor compound.

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Kenilworth, NJ, United States of America

Helmut Kropp