Schering Aktiengesellschaft

Id Pharma Gmbh

Kasch, Helmut

Helmut Kasch

Kurt Ponsold

Anatoli Kurischko

Gudrun Bertram

Gerd Schubert

Bernd Menzenbach

Heidemarie Rohrig

Reimar Krieg

Johannes Roemer

Winfried Schumann

Anatoil Kurischko

Joerg Steinbach

Uwe Reuter

Ralf Oettmeier

A novel class of gonane type and D-homo-gonane type steroids having sulfatase-inhibiting and/or estrogenic activity is presented for application in the pharmaceutical industry. The number and location of sulfamoyloxy groups on the steroids provides for sulfatase inhibiting and estrogenic activities that independently vary over a wide range, allowing the customization of the pharmaceutical for specific purposes, including treatment and diagnosis of estrogen-dependent tumors.

Steroid sulfamates, method for the production and use thereof

The invention relates to 11.beta.-aryl-gona-4,9-dienes of formula I ##STR1## wherein the variables are defined in the specification. The compounds are progesterone synthesis inhibitors and are suitable for inducing labor or an abortion, and for treating endometriosis, dysmenorrhea, and endocrine hormone-dependent tumors.

11 Beta-aryl-gona-4, 9-dien-3-ones

This invention relates to 11.beta.-aryl-gona-4,9-dienes of the general formula I ##STR1## wherein the variables are defined in the specification. The compounds are progesterone antagonists and are suitable for inducing labor or an abortion.

11.beta.-aryl-gona-4,9-dien-3-ones

11.sym.-Aryl-16.alpha.,17.alpha.-cyclohexano-estra-4,9-dienes of formula ##STR1## wherein R.sup.1 is H or a methyl group;

11.beta.-aryl-16.alpha.,17.alpha.-cyclohexano-estra-4,9-dienes

11.beta.-substituted-16.alpha., 17.alpha.-methylene-estra-4,9-dien-3-ones of formula I ##STR1## wherein R.sup.1 is a methyl or ethyl group;

11.beta.-substituted 16.alpha., 17.alpha.-methylene-estra-4,9-dien-3-ones

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Jena, Germany

Helmut Kasch