Bayer Aktiengesellschaft

Helmut Heitzer

Gunther Beck

Klaus Lurssen

Wilhelm Brandes

Robert R Schmidt

Ingeborg Hammann

Ludwig Eue

Hans Scheinpflug

Bernd Baasner

Klaus Sasse

Hans Holtschmidt

Albrecht Marhold

Andreas Knorr

Stanislav Kazda

Klaus Schaller

Ernst Kysela

Hans-Joachim Kabbe

Claudia Hirth-Dietrich

Friedrich W Krock

Arend Heise

Friedrich Hoffmeister

Fritz Doring

Karl Heinrich Mayer

Wolfgang Von Der Emden

Klaus Scaller

The reaction of cyanoolefins, aminocarbonylolefins or hydroxyiminoolefins with a Vilsmeier reagent leads to 2-halogenopyridines which bear aldehyde groups in the 3 and/or 5 position. These pyridinealdehydes are valuable intermediates for the preparation of pharmaceuticals and crop protection agents.

Process for the preparation of 2-halogenopyridinealdehydes and novel

1-Trifluoromethyl-1-nitro-2-alkoxy-2-aryl-ethanes of the formula ##STR1## in which R.sup.1 represents a straight-chain or branched alkyl radical and

1-trifluoromethyl-1-nitro-2-alkoxy-2-aryl-ethanes, their preparation and

The present invention relates to new substituted benzoxazepines and benzothiazepines of the general formula I ##STR1## in which X, R.sup.1, R.sup.2 and R.sup.3 have the meaning given in the description, processes for their preparation and their use in medicaments having vaso- and muscle-relaxing properties, in particular as circulatory agents.

Substituted benzoxazepines and benzothiazepines

The invention relates to new fluoromethylated polycyanobenzenes of the formula ##STR1## in which X represents hydrogen, fluorine or chlorine,

Fluoromethylated polycyanobenzenes, their alkali metal cyanide adducts,

A process for the preparation of 2-chloro-5-chloromethyl-thiazole of the formula: ##STR1## comprising reacting allyl isothiocyanate of the formula

Preparation of 2-chloro-5-chloromethylthiazole

4,5-Dichloroimidazole-2-carboxylic acid derivatives of the formula ##STR1## in which the group ##STR2## represents a carbon atom which has three bonds to hetero-atoms, and their salts with bases, possess insecticidal, acaricidal, fungicidal, nematicidal and herbicidal properties.

4,5-Dichloroimidazole-2-carboxylic acid derivatives

The imidazole-2-carboxylic acid amides of the general formula ##STR1## in which R represents alkyl, have powerful growth-regulating properties. The invention provides a method of regulating the growth of plants, which comprises applying to the plants, or to a habitat thereof, a compound of the formula (I) alone or in the form of a composition containing as active ingredient a compound of the formula (I) in admixture with a diluent or carrier.

Plant growth regulant compositions

Acyloxamide compounds of the formula ##STR1## in which R is chlorine, alkyl of from 1 or 2 carbon atoms or chloroalkyl of from 1 or 2 carbon atoms and 1 to 5 chlorine atoms e.g., 2,2-dichloropropionyl-oxamide and trichloroacetyl-oxamide are outstandingly effective as plant growth regulants. sp

Novel acyloxamides and plant growth regulant compositions

The invention covers compounds of the formula ##STR1## in which R.sup.1 and R.sup.5 each represents 0, 1, 2, 3 or 4 of the following substituents: alkyl, hydroxyl, acyloxy, alkoxy, nitro, amino, alkylamino, dialkylamino, acylamino, acylalkylamino, alkoxycarbonylamino, halogen, trifluoromethyl, cyano, carboxyl, alkoxycarbonyl, aminocarbonyl, alkylaminocarbonyl, dialkylaminocarbonyl, aminosulphonyl, alkylaminosulphonyl, dialkylaminoamino, R.sup.2 is hydrogen, optionally substituted alkyl, aralkyl or aryl or heterocyclo-alkyl, acyl or alkoxycarbonyl, and R.sup.3 and R.sup.4 are each hydrogen, or optionally substituted alkyl, aralkyl, aryl or hetero-aryl, are useful as medicaments which have an action on the central nervous system, in particular as, for example, tranquilizers and/or antiamnesics. Also included in the invention are methods for preparing said compounds, compositions containing them and methods for the use of said compounds and compositions.

Benzodiazepine-diones, a process for their production and their use as

Process for the preparation of 2,4,5-trichloropyrimidine, characterized in that compounds of the formula ##STR1## wherein R a radical which can be split off under the reaction conditions and

Process for the preparation of 2,4,5-trichloropyrimidine

Process for the preparation of 2,4,5-trichloropyrimidine, characterized in that compounds of the formula ##STR1## wherein R = a radical which can be split off under the reaction conditions Are reacted with more than 7 and less than 13 mols of chlorine, in particular 11 mols of chlorine, at temperatures from 0 - 40.degree. C. and the reaction mixture is then subsequently heated in the absence of chlorine to temperatures from about 100 - 150.degree. C., in particular 110 - 140.degree. C.

Process for the preparation of tetrachloropyrimidine, characterized in that compounds of the formula ##STR1## wherein R = a radical which can be split off under the reaction conditions, Are reacted with chlorine or agents which release chlorine, preferably at temperatures from 0.degree.-150.degree. C and using more than 7 mols of chlorine, in particular using 11-13 mols of chlorine.

Process for the preparation of tetrachloropyrimidine

Process for the preparation of tetrachloropyrimidine, characterized in that compounds of the formula ##STR1## wherein R = a radical which can be split off under the reaction conditions and

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Leverkusen, Germany

Helmut Heitzer