Schering Aktiengesellschaft

Schering Aktiengellschaft

Helmut Dahl

Werner Skuballa

Karl Petzoldt

Helmut Vorbruggen

Alfred Weber

Mario Kennecke

Bernd Raduchel

Helmut Vorbrueggen

Olaf Loge

Karl-Heinz Thierauch

Ernst Schottle

Rudolf Wiechert

Henry Laurent

Klaus Annen

Ralph Lipp

Hans Wendt

Klaus Kieslich

Claus-Steffen Stuerzebecher

Joachim-Friedrich Kapp

Torsten Wagner

Hans Peter Lorenz

Reinhold Wieske

Heinrich Michel

J&uuml;rgen Westermann

Bernd Iffert

Gabriela Buttner

Dieter Peschel

Martin Wessel

Werner Skubalia

The invention relates to the use of an oxidation inhibitor, i.e. active carbon, for ambient air in industrial manufacturing, especially in the processing of prostane derivatives, whereby the oxidation inhibitor removes ozone from the process air before contact with said prostane derivatives. The concentration of decomposition products is reduced.

Oxidation inhibitors in prostane derivatives

A process for production of 15-alpha-hydroxyprostaglandin intermediates of formula I ##STR1## wherein X is CH.sub.2,

Microbiological reduction of prostacyclin intermediate products with a

Racemic separation of

Keto reduction of carbacyclin intermediates

Stereospecific keto reduction of bicyclooctandione-carboxylic acid

The invention relates to cyclodextrin clathrates of 5-cyanoprostacyclin analogs.

Cyclodextrin clathrates of 5-cyanoprostacyclin derivatives and their use

Novel process for manufacturing optically active carbacyclin

5-Cyanoprostacyclins of Formula I ##STR1## wherein A is a --CH.sub.2 --CH.sub.2 --, trans--CH.dbd.CH--, or --C.tbd.C-group,

Novel prostacyclin derivatives, process for the preparation thereof, and

Racemic dissociation of 3-acyloxy bicyclo(3.3.0)octan-7-one-2-carboxylic

Cyclodextrin clathrates of carbacyclin analogs of general Formula I ##STR1## wherein R.sub.1 is hydrogen, alkyl or alkenyl of up to 10 carbon atoms,

Cyclodextrin clathrates of carbacyclin derivatives and their use as

A process for the preparation of a 15 .alpha.-hydroxyprostaglandin intermediate of the formula ##STR1## wherein R.sub.1 is phenoxymethyl, phenoxymethyl substituted on the phenyl moiety by halogen or trifluoromethyl, or alkyl of 1-5 carbon atoms, and

Microbiological reduction of 15-ketoprostaglandin intermediates

Steroids of the formula ##STR1## wherein represents a single or double bond,

Novel steroids of the pregnane series, substituted in the 17-position,

Corticoids of the formula ##STR1## wherein represents a single bond or a double bond;

Novel 17-substituted 11 .beta.-hydroxy steroids of the pregnane series,

The side chains of sterols are degraded by fermentation with microorganisms capable of doing so in an improved manner by employing in such fermentations sterol derivatives of the formula ##STR1## wherein n is 1 or 2; R.sub.1 is H or lower alkyl, R.sub.2 is alkyl, whose chain optionally is interrupted by an oxygen atom, or when n is 2, also a hydrogen atom; and R.sub.3 is a sterol side chain.

Microbiological degradation of sterol side chains to a 17-keto group

Bicycloalkanes of the formula ##STR1## WHEREIN N IS THE INTEGER 1 OR 2; R is methyl or ethyl, and X and Y collectively are a free or ketalized oxo group or X is a hydrogen atom and y is a free, etherified or esterified hydroxy group, are produced by hydrogenating a compound of the formula ##STR2## WHEREIN N, R, X, and Y have the values given above and Me is an alkali metal atom, in an aqueous solution with hydrogen and a palladium-, platinum- or rhodium-containing hydrogenation catalyst. The corresponding free acid is obtained by acidifying the reaction mixture and isolating the reaction product.

Process for the preparation of bicycloalkane derivatives

Growing community of inventors

Berlin, Germany

Helmut Dahl