Gruenenthal Gmbh

Grunenthal Gmbh

Helmut Buschmann

Bernd Sundermann

Hagen-Heinrich Hennies

Babette-Yvonne Koegel

Corinna Sundermann

Wolfgang Hell

Heinz Uragg

Werner Guenter Englberger

Corinna Maul

Markus Kegel

Hans Schick

Elmar Josef Friderichs

Joerg Holenz

Andreas Fischer

Michael Przewosny

Michael Gruss

Wolfgang Werner Strassburger

Michael Sattlegger

Dagmar Lischke

Detlef Heller

Felix Spindler

Oswald K Zimmer

Beatrix Merla

Tieno Germann

Bernd Clement

Stefanie Frosch

Fritz Theil

Boris Chizh

Michael Finkam

Dieter Heber

Hans-Joachim Drexler

Stefan Gladow

Hartmut Loebermann

Bernhard Akteries

Ullvi Bluhm

Jorg Holenz

Harmut Loebermann

Corinne Maul

Ulrich Wolschendorf

Hans-Joachin Drexler

Nikolaus Risch

Barbara Heller

Michael Haubrand

Compounds of the formula II can be hydrogenated to the corresponding butane derivatives in the presence of homogeneous cataslysts composed of metal salts or complexes containing metals selected from the group consisting of Rh, Ir, and Ru and preferably containing diphosphine ligands, with, in addition, excellent optical yields being achieved when one of Rand Ris not a hydrogen atom and the diphosphine ligand is chiral.

Process for preparing a substituted dimethyl-(3-arylbutyl)amine compound by homogeneous catalysis

This invention relates to solid crystalline forms of (1RS,3RS,6RS)-6-Dimethylaminomethyl-1-(3-methoxy-phenyl)cyclohexane-1,3-diol hydrochloride (1), methods of producing 1, methods of use of 1, use of 1 as analgesics and pharmaceutical compositions comprising 1.

Crystalline forms of (1RS,3RS,6RS)-6-dimethylaminomethyl-1-(3-methoxyphenyl)cyclohexane-1,3-diol hydrochloride

A hitherto unknown crystalline form of (&#x2212;)-(1R,2R)-3-(3-dimethylamino-1-ethyl-2-methylpropyl)-phenol hydrochloride, pharmaceutical compositions containing the new crystalline form, methods of producing the new crystalline form, and a related method of use including treatment of, e.g., pain and/or urinary incontinence.

Crystalline forms of (&#x2212;)-(1R,2R)-3-(3-dimethylamino-1-ethyl-2-methylpropyl)-phenol hydrochloride

Pharmaceutical formulations comprising N,N'disubstituted piperazine compounds and related methods of treatment using these formulations.

Pharmaceutical formulations comprising N,N'-disubstituted piperazine compounds

Substituted 3-phenylpiperidine compounds corresponding to Formula I in which R1 and R2 have the meanings defined in the specification, methods for preparing such compounds, pharmaceutical compositions containing such compounds, and the use of such compounds for treating or inhibiting various conditions, especially pain.

Substituted 3-phenylpiperidine compounds, their preparation and use

Substituted 1,5-diaminopentan-3-ol compounds and methods of making the same. Pharmaceutical compositions containing these compounds and methods of treatment using these pharmaceutical compositions.

1, 5-diaminopentan-3-ol compounds and related treatment methods

Pharmaceutically active salts and esters of 1-dimethylamino-3-(3-methoxyphenyl)-2-methylpentan-3-ol and 3-(3-dimethylamino-1-ethyl-1-hydroxy-2-methylpropyl)-phenol, and methods of using the same for treating or inhibiting increased urinary urgency or urinary incontinence and/or pain.

Pharmaceutically active salts and esters of 1-dimethylamino-3-(3-methoxyphenyl)-2-methylpentan-3-ol and 3- (3-dimethylamino-1-ethyl-1-hydroxy-2-methylpropyl)-phenol and methods of using same

Pharmaceutical compositions containing substituted aminoalcohols, the use of preparations containing substituted aminoalcohols for treatment of conditions such as pain, emesis, neurotropic conditions, cardiovascular diseases, urinary incontinence, diarrhea, pruritus, alcohol or drug dependency, inflammation, depression, decreased vigilance, or depressed libido, as well as 2-(aminomethyl)cycloalkane-1-ol compounds and a process for their preparation.

Pharmaceutical preparations comprising substituted beta-aminoalcohols

Methods for the dehydration of substituted 1-amino-3-aryl-butan-3-ol compounds for the preparation of substituted 3-aryl-butyl-amine compounds.

Process for the preparation of substituted 3-aryl-butylamine compounds

N,N'-disubstituted piperazine compounds, processes for the production thereof, and pharmaceutical preparations containing these compounds. The use of N,N&#x2032;-disubstituted piperazine compounds for the production of pharmaceutical preparations and in related methods of treatment.

N, N'-disubstituted piperazine compounds and their use as analgesics

The invention relates to substituted pyrido[1,2-a]pyrimidine compounds corresponding to formula (I) wherein:

Substituted pyrido(1,2-a)pyrimidines and their use as NOS inhibitors

Novel 2-pyrrolidin-2-yl-1H-indole compounds corresponding to formula (I) wherein R, R, Rand Rhave the meanings given in the description, and pharmaceutical compositions containing these compounds, as well as processes for the preparation of such compounds and intermediate products of this process, and related methods of treatment.

Substituted 2-pyrrolidine-2-yl-1H-indole compounds

The present invention relates to a process for converting a tertiary OH group of an organic compound into a tertiary Cl group of the organic compound by using a solvent selected from the group comprising toluene, o-xylene, m-xylene, p-xylene and mixtures thereof, and thionyl chloride as the chlorinating agent.

Process for chlorinating tertiary alcohols

Substituted propane-1,3-diamine derivatives, methods for producing such derivatives, and medicaments and pharmaceutical compositions containing such derivatives useful for the treatment or prophylaxis of pain, urinary incontinence, itching, tinitus aurium, or diarrhea are provided.

Substituted propane-1,3-diamine derivatives and the pharmaceutical use thereof

Substituted indoles of the formula I, a process for the production of such compounds, pharmaceutical preparations containing these compounds and the use of these compounds for alleviating pain.

Substituted indoles, process for the production thereof and use thereof for combatting pain

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Esplugues de Llobregat, Spain

Helmut Buschmann