Dr. Karl Thomae Gmbh

Helmut Ballhause

Josef Nickl

Walter Haarmann

Gunther Engelhardt

Erich Muller

Norbert Mayer

Willy Roth

Alex Prox

Claus A Landgraf

Benthold Narr

Kurt Schumacher

Novel compounds of the general formula ##STR1## which have antitussive activity, wherein R.sub.1 -R.sub.4 are as defined herein.

Substituted 6-benzyl-2H-3,4,5,6-tetrahydro-(1,3)-oxazines

This invention relates to a compound of formula (I) ##STR1## wherein R.sub.1 and R.sub.2 are each independently hydrogen, C.sub.1 -C.sub.3 alkyl or C.sub.1 -C.sub.3 alkoxy; and R.sub.3 is a C.sub.7 -C.sub.9 aralkyl, the phenyl nucleus of which can be mono-, di-, or trisubstituted by halogen, C.sub.1 -C.sub.3 alkyl or C.sub.1 -C.sub.3 alkoxy, and nontoxic, pharmaceutically acceptable salts thereof. The compounds have useful antithrombic properties.

Quaternary 3,4-dihydro-isoquinolinium salts

Growing community of inventors

Biberach, Germany

Helmut Ballhause