Warner-lambert Company

Godecke Aktiengesellschaft

Helmut Augart

Adolf Knecht

Uwe Gebhardt

Wolfgang Dieter Herrmann

The present invention concerns cyclic amino acids of formula ##STR1## substantially free from the lactam ##STR2## wherein n is an integer of from 4 to 6, a process for the preparation thereof, compositions containing the compounds and methods of using them.

Lactam-free amino acids

The present invention provides a process for the timed control of the liberation of active material from a retarded active material-containing composition by the addition of a hydrophilic polymer, wherein the rate of liberation is adjusted by means of the viscosity of the added hydrophilic polymer, the rate of liberation increasing with increasing viscosity.

Process for time-controlled release of active ingredients

The present invention provides a process for the production of a pharmaceutical composition with a retarded liberation of active material, wherein an active material in finely divided form is mixed with a finely divided high melting and a low melting lipid or lipoid component, the mixture is brought to a temperature which is above the melting point of the low melting component but below the melting point of the high melting component and the mixture, after melting of the low melting component, is allowed to cool to below the melting point thereof and subsequently worked up in known manner to give a finished pharmaceutical composition.

Process for the manufacture of a pharmaceutical composition with a

The present invention provides a pharmaceutical composition containing at least one oxicam derivative of the general formula: ##STR1## in which R is a heterocyclic ring and X together with Y represent a condensed aromatic ring, together with a more than equimolar amount of an organic base of the general formula:

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Waldkirch, Germany

Helmut Augart