Syngenta Participations Ag

Syngenta Corporation

Syngenta Crop Protection Ag

Helmars Smits

Tomas Smejkal

Edouard Godineau

Thomas Pitterna

Jerome Yves Cassayre

Pierre Joseph Marcel Jung

Ottmar Franz Hueter

Alan James Robinson

Michel Muehlebach

Myriem El Qacemi

Christian Lothschuetz

Miroslav Terinek

Sophie Pelletier

Jochen Weckesser

Andrew Edmunds

Peter Renold

André Stoller

Jérôme Yves Cassayre

Denis Gribkov

Sebastian Volker Wendeborn

Guillaume Berthon

Regis Jean Georges Mondiere

Raphael Dumeunier

Mattia Riccardo Monaco

Nicholas Phillip Mulholland

Régis Jean Georges Mondiere

Christopher Charles Scarborough

Mohamed Abdelouahab Boussemghoune

Matthias Becker

Thomas Klatt

Paul Knochel

Michael Christian Dieckmann

The present invention provides, inter alia, a process for producing a compound of Formula (I): wherein A, R, R, R, R, Rand Rare as defined herein. The present invention further provides intermediate compounds utilised in said process, and methods for producing said intermediate compounds. 

Process for producing herbicidal pyridazinone compounds

The present invention relates to compounds of formula (I) having insecticidal activity to processes and interediates for preparing them, to insecticidal, acaricidal, nematicidal or molluscicidal compositions comprising them and to methods of using them to combat and control insect, acarine, nematode or mollusc pests 

Insecticidal compounds

A process for making certain spiroheterocyclic pyrrolidine dione derivatives.

Process for the preparation of a spiroheterocyclic pyrrolidine dione

The invention relates to a process for the preparation of compound of formula (I) wherein Ris halogen and Ris halogen or hydrogen; comprising a) reacting the compound of formula (II) in an aprotic organic solvent in the presence of an aprotic polar co-solvent with a magnesium amide base followed by a halogenating agent, to the compound of formula I wherein Ris halogen and Ris hydrogen, and b) reacting the compound of formula (I), wherein Ris chloro and Ris hydrogen, in an aprotic organic solvent in the presence of an aprotic polar co-solvent with a magnesium amide base followed by a halogenating agent to a compound of formula I, wherein Ris chloro and Ris halogen. 

Process for the preparation of halo-substituted benzenes

The present invention relates to a process for the preparation of a compound of formula I (I), comprising reacting a compound of formula II (II), with a brominating agent in the presence of an acidic catalyst to a compound of formula III (III), and reacting the compound of formula III in tetrahydrofuran or 2-methyl-tetrahydrofuran with potassium tert-butoxide to a compound of formula I. 

Process for the preparation of 5-bromo-1,2,3-trichlorobenzene

Process for the preparation of spiroheterocyclic pyrrolidine diones

The present invention relates to a process for the preparation of a compound of formula (I) wherein Aand Aare C&#x2014;H, or one of Aand Ais C&#x2014;H and the other is N; Ris C-Calkyl, C-Chaloalkyl or C-Ccycloalkyl; each Ris independently bromo, chloro, fluoro or trifluoromethyl; Ris hydrogen; Ris hydrogen, halogen, methyl, halomethyl or cyano; or Rand Rtogether form a bridging 1,3-butadiene group; Ris chlorodifluoromethyl or trifluoromethyl; n is 2 or 3; by reacting a compound of formula (II) wherein A, A, R, R, R, R, Rand n is as defined under formula (I) above, with hydroxylamine, a base and a chiral catalyst, characterized in that the chiral catalyst is a dimeric chiral catalyst of formula (III) wherein R, R, R, R, Rand X are as defined in claim. 

Process for the preparation of optically active isoxazoline compounds

The present invention relates to processes for the preparation of substituted cycloserine compounds of formula (I) wherein Ris C-Calkyl, C-Chaloalkyl, C-Ccycloalkyl, aryl or aryl substituted by one to five R, or aryl-C-Calkylene or aryl-C-Calkylene substituted by one to five R; andeach Ris independently C-Calkyl, C-Chaloalkyl, C-Calkoxy, C-Chaloalkoxy, cyano or halogen; The invention also relates to intermediates produced by the processes. Compounds of formula (I) are useful intermediates for the production of compounds in the agricultural and pharmaceutical fields.

Process for the preparation of substituted cycloserines

The invention relates to a process for the preparation of a compound of formula I comprising a) reacting a compound of formula II in the presence of magnesium or an organometallic reagent of formula III RMX (III), wherein Ris C-Calkyl; Mis Li or Mg and X is halogen or absent; with a compound of formula IV CF&#x2014;C(O)&#x2014;R(IV), wherein Ris halogen, hydroxyl, C-Calkoxy, (di-C-Calkyl)amino, OC(O)CF, phenoxy or OM; wherein Mis Lithium, Magnesium, Sodium or Potassium; to a compound of formula V, and b) reacting the compound of formula V with alkali metal fluoride in the presence of catalytic amounts of a phase transfer catalyst in the presence of a polar solvent to the compound of formula I. 

Process for the preparation of 1-(3,5-dichloro-4-fluoro-phenyl)-2,2,2-trifluoro-ethanone

The present invention relates to novel triazole derivatives of formula (I) having insecticidal activity, to processes and intermediates for preparing them, to insecticidal, acaricidal, nematicidal or molluscicidal compositions comprising them and to methods of using them to combat and control insect, acarine, nematode or mollusc pests; wherein R, R, G, G, Qand Qare as defined in claim; or salts thereof. 

The present invention relates to processes for the preparation of substituted cycloserine compounds of formula (I) wherein Ris C-Calkyl, C-Chaloalkyl, C-Ccycloalkyl, aryl or aryl substituted by one to five R, or aryl-C-Calkylene or aryl-C-Calkylene substituted by one to five R; and each Ris independently C-Calkyl, C-Chaloalkyl, C-Calkoxy, C-Chaloalkoxy, cyano or halogen; The invention also relates to intermediates produced by the processes. Compounds of formula (I) are useful intermediates for the production of compounds in the agricultural and pharmaceutical fields.

The present invention provides a novel and improved process for the production of the production of hindered anilines containing perfluoroalky groups in good yield any by using close to stoichiometric amounts of acylating agent.

Process for the preparation of amides from hindered anilines containing a perhaloalkyl group

The present invention relates to processes for the enantio-selective preparation of spyrrolidine derivatives useful in the manufacture of pesticidally active compounds, as well as to intermediates in the processes. The processes include those comprising (a-i) reacting a compound of formula Ia whereinP is alkyl, aryl or heteroaryl, each optionally substituted, wherein the heteroaryl is connected at P via a ring carbon atom;Ris chlorodifluoromethyl or trifluoromethyl;Ris aryl or heteroaryl, each optionally substituted;with a source of cyanide in the presence a chiral catalyst to give a compound of formula IIa wherein P, Rand Rare as defined for the compound of formula Ia; and(a-ii) oxidizing the compound of formula IIa with a peroxy acid, or peroxide in the presence of an acid to give a compound of formula VI wherein Rand Rare as defined for the compound of formula Ia.

Processes for the preparation of pyrrolidine intermediates

The present invention provides stereoselective processes for the preparation of compounds of formula (I) wherein P is phenyl, naphthyl, a 6-membered heteroaryl group containing one or two nitrogen atoms as ring members, or a 10-membered bicyclic heteroaryl group containing one or two nitrogen atoms as ring members, and wherein the phenyl, naphthyl and heteroaryl groups are optionally substituted; Ris chlorodifluoromethyl or trifluoromethyl; Ris optionally substituted aryl or optionally substituted heteroaryl; n is 0 or 1; including the process comprising (a-i) reacting a compound of formula II wherein P, Rand Rare as defined for the compound of formula I; with nitromethane in the presence a chiral catalyst to give a compound of formula III Wherein P, Rand Rare as defined for the compound of formula I; and (a-ii) reductively cyclizing the compound of formula III to give the compound of formula I. The invention also provides intermediates useful for processes for the synthesis of compounds of formula (I). 

Process for the preparation of dihydropyrrole derivatives

The present invention provides processes for the preparation of compounds of formula (I) including processes comprising a. reacting a compound of formula (II) with a nucleophile in the presence of water to give a compound comprising a thietane moiety in which the carbon atom at the 3 position of the thietane moiety is bonded to a nitrogen atom; wherein the nucleophile is selected the group consisting of: N, a sulfonamide having two hydrogen atoms bound to the nitrogen atom, a diimide having a hydrogen atom bound to the nitrogen atom or an anion thereof, NHOH and NH; and b. when the nucleophile used in step a. is Nor NHOH, reacting the compound produced in step a. with a suitable reducing agent to give a compound of formula (I); or when the nucleophile used in step a. is a sulfonamide, reacting the compound produced in step a. with a reagent suitable for cleaving the S&#x2014;N bond of the sulfonamide group to give a compound of formula (I); or when the nucleophile used in step a. is a diimide, reacting the compound produced in step a. with a reagent suitable for cleaving the C&#x2014;N bond of the amide group to give a compound of formula (I). The invention also relates to intermediates useful for the preparation of compounds of formula (I). 

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Stein, Switzerland

Helmars Smits