Evonik Degussa Gmbh

Degussa Aktiengesellschaft

Helge Werner

Harald Gröger

Werner Hummel

Harald Groeger

Claudia Rollmann

Karlheinz Drauz

Josef Altenbuchner

Hendrik Hüsken

Francoise-Christine Chamouleau

Dittmar Orzewski

Anne Menzel

Francoise Chamouleau

Chad Hagedorn

Françoise Chamouleau

A product is enriched by a method for the processing of a reaction solution, in which: a) a pH value of the reaction solution is adjusted to less than 4; wherein said reaction solution comprises a whole-cell catalyst, an aqueous component, and an organic component, wherein the organic component contains a product to be enriched; and b) the reaction solution is filtered in the presence of a filter aid, thereby enriching the product.

Processing of reaction solutions from whole-cell biotransformations

The present invention relates to a process for preparing, in particular, enantiomerically enriched L-&#x3b1;-amino acids, in particular those of the general formula (I). In this connection, the process according to the invention uses 2-ketocarboxylic acids which are converted into the desired products using a whole-cell catalyst which comprises an amino acid dehydrogenase and a cofactor-regenerating enzyme. 

Process for preparing optically active amino acids using a whole-cell catalyst

The present application relates to a reaction system in which chemically valuable compounds can be obtained in high enantiomer concentrations with the aid of a coupled enzymatically operating transformation process. The coupled enzymatic reaction system comprises a cofactor-dependent enzymatic transformation of an organic compound and an enzymatic regeneration of the cofactor, wherein the reaction system operates in aqueous solution with an amount of substrate above the solubility limit thereof. In the preferred embodiments, an alcohol dehydrogenase is the cofactor-dependent enzyme, and the regeneration of the cofactor (e.g. NADH or NADPH) is acheved by means of formate dehydrogenase.

Coupled cofactor-dependent enzymatic reaction systems in aqueous media

The present invention relates to processes for the preparation of enantiomerically enriched &#x3b2;-amino acids. The invention also relates to advantageous esters of &#x3b2;-amino acids of the general formula (I)and to the use thereof in the enzymatic preparation of enantiomerically enriched &#x3b2;-amino acids.

Process for the enzymatic preparation of enantiomer-enriched &#x3b2;-amino acids

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Bruchköbel, Germany

Helge Werner