Nycomed Imaging As

Ge Healthcare As

Amersham Health As

Helge Tolleshaug

Jo Klaveness

Alan Cuthbertson

Magne Solbakken

P&aring;l Rongved

Lars Hoff

Halldis Hellebust

Anders H&oslash;gset

Anne Naevestad

Anne N&aelig;vestad

Dagfinn L&oslash;vhaug

Klaus Bryn

Aslak Godal

Hege Karlsen

Geir Gogstad

The present invention provides novel compounds and pharmaceutical compositions containing such compounds, wherein the compounds have affinity for proteoglycans. The compounds comprise an amino acid based core unit linked to positively charged moieties. The compounds further comprise at least one imaging moiety detectable in in vivo imaging making the compounds useful as diagnostic contrast agents for imaging of proteoglycans, such as heparan sulphate proteoglycans.

Contrast agents

The invention provides a composition of matter of the formula (I): V-L-R, where V is a vector moiety having affinity for an angiogenesis-related endothelias cell receptor, L is a linker moiety or a bond and R is a detectable moiety, characterised in that V is a non-peptidic organic group, or V is peptidic and R is a macromolecular or particulate species providing a multiplicity of labels detectable in in vivo imaging.

Targetable diagnostic and/or therapeutically active agents, e.g. ultrasound contrast agents, comprising a suspension in an aqueous carrier liquid of a reporter comprising gas-containing or gas-generating material, said agent being capable of forming at least two types of binding pairs with a target.

Diagnostic/therapeutic agents

The invention provides a composition of matter of the formula (I): V&mdash;L&mdash;R, where V is a vector moiety having affinity for an angiogenesis-related endothelias cell receptor, L is a linker moiety or a bond and R is a detectable moiety, characterized in that V is a non-peptidic organic group, or V is peptidic and R is a macromolecular or particulate species providing a multiplicity of labels detectable in in vivo imaging.

Targeted diagnostic/therapeutic agents having more than one different vectors

Targetable diagnostic and/or therapeutically active agents, e.g. ultrasound contrast agents, having reporters comprising gas-filled microbubbles stabilised by monolayers of film-forming surfactants, the reporter being coupled or linked to at least one vector.

Diagnostic/therapeutic agents having microbubbles coupled to one or more vectors

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Oslo, Norway

Helge Tolleshaug