Nycomed Imaging As

A/s Farmaceutisk Industri

Helge G Gundersen

Jo Klaveness

Per Strande

Anne Kjersti Fahlvik

Anne N&aelig;vestad

Anne Jacobsen

The invention relates to particulate contrast agents, especially contrast agents for MR imaging having a metal oxide core which is preferably superparamagnetic iron oxide. The particulate contrast agents are provided with a low coating density of a polyelectrolyte coating agent selected from structural polysaccharides and synthetic polymers, especially polyaminoacids. Unlike conventional coated particulates, the new particles have reduced or no effect on cardiovascular parameters, platelet depletion, complement activation and blood coagulation.

Ultrafine lightly coated superparamagnetic particles for MRI

There is provided a contrast medium composition comprising magnetically responsive particles and a physiologically tolerable, incompletely hydrated viscosity enhancing agent.

Contrast medium comprising superparamagnetic or ferromagnetic particles

Composition of a superparamagnetic or ferromagnetic particle and an

There are disclosed new hexamethylene-bis-biguanides having antibacterial activity, and two processes for the preparation thereof. The new compounds have the general formula ##STR1## wherein R represents H, and R' represents an hexyl or pentyl group being substituted with one or two methyl groups, or represents a cycloalkyl group having more than 6 carbon atoms, a lower-alkyl-cycloalkyl group or a cycloalkyl-lower-alkyl group, or R and R' together with the adjacent nitrogen atom represent an azabicyclo(3,2,2)-nonane double ring.

Antibacterially active hexamethylene-bis-biguanides

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Oslo, Norway

Helge G Gundersen