Acuros Gmbh

Other

Famlee Fund Gmbh

Waldwieseholz Gmbh

Helge Adleff

Rudolf Ehwald

Max Ehwald

Frank Bier

Holger Woehlecke

Nenad Gajovic-Eichelmann

Thilo Guschauski

Thilo Philipp Guschauski

Rudolf Johannes Ehwald

An osmotic pump comprises a first chamber () comprising an osmotically active substance (), a second chamber () arranged to be filled with a solvent (), and a semi-permeable barrier () separating the first chamber () from the second chamber (). The semi-permeable barrier () is impermeable to the osmotic active substance and permeable to the solvent (). The osmotic pump further comprises a pressure device () in fluid communication with the second chamber (), wherein the pressure device () is arranged for pressurizing the solvent in the second chamber.

Osmotic pump comprising a pressure device for pressurizing the solvent

The invention refers to a method for control of a volume flow in an osmotic micropump and an osmotic micropump. According to the invention, the osmotically driven volume flow of the solvent through the sempipermeable diaphragm of an osmotic micropump is controlled by the transfer of a solute, which is not freely permeable through the diaphragm, from a source chamber to the pump's delivery chamber. According to the invention, the delivery chamber is formed as a dilution chamber, wherein the solution is flow out along a convective dilution path close to the semipermeable diaphragm. Due to the entrance of the solvent, a stationary osmotic gradient can be achieved along the convective flow path in the dilution chamber. The invention allows the maintenance and control of the flow rate. It is able to move a volume which is large in comparison to the combined volume of the source chamber and the dilution chamber.

Method for control of the volume flux of a liquid in an osmotic micropump and osmotic micropump

The invention relates to an assay method and a fluid microsystem for carrying out said assay method, in particular, for carrying out miniaturized affinity tests in a micro-array format. According to said invention, a liquid phase comprising at least one type of detectable high-molecular weight soluble substance, for example a labeled reaction partner or product of an affinity reaction is displaced by the hydraulic effect of a high-molecular weight osmotic agent on an ultrafiltration membrane towards a miniaturized measuring chamber defined thereby. The fraction of the detectable high-molecular weight substance(s) is concentrated in the measuring chamber, while the dissolved low-molecular weight components are removed with the solvent through the membrane pores, thereby making it possible to attain a high detection sensitivity.

Assay by osmotically induced separation and concentration of high-molecular detectable substances and a fluid microsystem for carrying out said assay

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Berlin, Germany

Helge Adleff