Gyros Ab

Gyros Patent Ab

Ge Healthcare Bio-sciences Ab

Helene Derand

Per X Andersson

Anders Larsson

Magnus Gustafsson

Anders Palm

Sussanne Wallenborg

Susanne Wallenborg

James Van Alstine

Gunnar Ekstrand

Lars Rune Lundbladh

Gunnar Thorsen

Mats Inganas

Susanna Lindman

Mats Inganäs

Rose Nasman, Legal Representative

Harry Nasman, Legal Representative

Ebru Togan-Tekin

Olle Larsson

Ulrike Selditz

Anette Ocklind

Frida Jernstrom

Cecilia Hellermark

A microfluidic device comprising one, two or more microchannel structures (-), each of which comprises a reaction microcavity (-) intended for retaining a solid phase material in the form of a wet porous bed. Each of said one, two or more microchannel structures comprises the solid phase material in a dry state together with a bed-preserving agent comprising one or more compounds having bed-preserving activity.

Preloaded microfluidic devices

A microfluidic device comprising a set of one or more, preferably more than 5, covered microchannel structures manufactured in the surface of a planar substrate. The device is characterized in that a part surface of at least one of the microchannel structures has a coat exposing a non-ionic hydrophilic polymer. The non-ionic hydrophilic polymer is preferably attached covalently directly to the part surface or to a polymer skeleton that is attached to the surface.

Microfluidic surfaces

A method for covering a set of open microchannel structures which are fabricated on a planar surface made of plastics and which comprise two or more part areas that have different surface characteristics. The method comprises the steps of: a) providing the surface comprising the set of microchannel structures; b) providing a lid-forming sheet having on one side an even layer of a thermoglue; c) applying the side of the sheet having the thermoglue against the surface carrying the microchannel structure; d) heating the assembly created in step (c) to selectively liquefy the hot-melt adhesive while at the same time pressing the sheet material and the planar surface of the substrate together; e) permitting the resulting laminate-covered microchannel structure to cool. An assembly comprising (a) a planar substrate, the surface of which has a set of one or more open microchannel structures each of which comprises part areas representing different functionalities, and (b) a lid-forming material covering said set of microchannel structures and having one or more openings going from a microchannel structure to ambient atmosphere. The assembly is characterized in that the joint between said surface and said sheet material is a thermoglue that possibly has been cured.

Method for covering a microfluidic assembly

A microfluidic device that comprises several microchannel structures in which there are an inlet port, an outlet port and therebetween a substructure comprising a fluidic function. The device has an axis of symmetry around which the microchannel structures are arranged as two or more concentric annular zones. for an inlet port and an outlet port of the same microchannel structure the inlet port is typically closer to the axis of symmetry than the outlet port. Each microchannel structure comprises a substructure that can retain liquid while the disc is spun around the axis and/or the inlet ports are positioned separate from the paths waste liquid leaving open waste outlet ports will follow across the surface of the disc when it is spun. For the microchannel structures of an annular zones the corresponding substructures are at essentially at the same radial distance while corresponding substructures in microchannel structures of different annular zones are at different radial distances. The invention also refers to several other substructures. The substructure are primarily adapted for transporting liquid aliquots that have a surface tnsion &#x3e;5 mN/m with centrifugal force.

Structural units that define fluidic functions

A method for hydrophilization and/or surface area enlargement of a porous base matrix comprising on its inner and/or outer surfaces a polymer (P') carrying nucleophilic groups X&#x2032;. The method is characterized in A support matrix which is obtainable by the method. The support matrix has a sufficient rigidity and swellability to permit liquid flow of a velocity &#x3e;5 cm/h through the matrix when in form of particles packed to a bed or in form of a porous monolithic plug. The use of the support matrix defined in liquid chromatography, cell culturing, stepwise solid phase synthesis of organic molecules, affinity adsorption in suspensions, solid phase catalysis with an immobilized catalyst.

Method for surface modification, a novel support matrix and the use of the matrix

A method for increasing the yield of functional microchannel structures per microfluidic device in the manufacturing of microfluidic devices each of which comprises a plurality of enclosed microchannel structures, said manufacturing comprising the manufacture of a microfluidic device which comprises enclosed microchannel structures by joining a substrate surface I of a first generally planar plastic substrate I to a substrate surface II of a second generally planar substrate II via a bonding material.

Microfluidic device and its manufacture

The present invention relates to a method for presenting an analyte of a liquid sample as an MS-analyte to a mass spectrometer. More particularly, the method comprises the steps of applying a liquid sample containing the analyte to a sample inlet port of a microchannel structure of a microfluidic device, said structure also comprising an outlet port (MS-port) that is capable of being interfaced with a mass spectrometer, passing the analyte to the MS-port thereby transforming it to an MS-analyte, and presenting the MS-analyte to mass spectrometer via the MS-port.

Microfluidic system

The invention relates to a method of controlling flow of liquids in a micro channel structure. It comprises providing in said micro channel structure plugs () of polymer material in said structure, said polymer material in a first state blocking said channel from liquid flow, and in a second state providing a free path-way () for liquid flow. Energy is selectively applied so as to cause said polymer to enter a desired one of said first or second states. It also relates to a micro channel valve system, comprising a plurality of such plugs (). Additionally it comprises a chemical reactor, comprising a plurality of micro chambers interconnected by micro channels, having a valve system according to the invention.

Polymer valves

A method for rendering a surface covered by a plastic material more hydrophilic by treatment with a gas plasma non-polymerizable gas. The method is characterized in that the intensity of the plasma is selected so that the surface becomes permanently more hydrophilic. Also disclosed is a naked plasma treated surface of plastic having an immediate water contact angle of &#x2266;30&#xb0;, said water contact angle is changed &#xb1;20 and/or less than 5% upon washing with an ethanol/water mixture (70% w/w).

Surface and its manufacture and uses

A microfluidic disc having one or more enclosed microchannel structures, and the microchannel structures are intended to be used for transport of transporting liquids. The device is characterized in that at least a part of the inner walls of each of one or more microchannel structures are treated with a gas plasma having one or more organic precursor compounds.

Microfluidic devices with new inner surfaces

A microfluidic device comprising an MS-analyte presentation unit for a EDI-MS apparatus, said unit comprising an essentially planar support plate which on one side has one, two or more ports (MS-ports) comprising an area (EDI area) for presenting the MS-analyte to a mass spectrometer. The EDI area comprises a layer I of conducting material. The characteristic feature of the device is that layer (I) has a conductive connection and/or that there is a calibrator area in the proximity of the MS-port.

Growing community of inventors

Taby, Sweden

Helene Derand