Merck Patent Gmbh

Merck Patent Gesellschaft MIT Beschrankter Haftung

Helene Crassier

Guenter Hoelzemann

Wilfried Rautenberg

Alfred Jonczyk

Wolfgang Staehle

Karl-August Ackermann

Jaume Adan

Elisabet Rosell-Vives

Christoph Seyfried

Kai Schiemann

Gerd Bartoszyk

Timo Heinrich

Joachim Leibrock

Andreas Bathe

Henning Böttcher

Henning Boettcher

Günter Hölzemann

Francesc Mitjans

Chrisoph Van Amsterdam

Steffen Emmert

Gema Tarrason

Claudia Cases

Marta Soler Riera

Uwe Eckert

Günter Hoelzemann

Compounds of the formula (I), in which R, Rand X have the meanings indicated in Claim, are inhibitors of tyrosine kinases, in particular TIE-2, and Raf kinases and can be employed, inter alia, for the treatment of tumours. 

N,N'-diphenylurea derivatives suitable as kinase inhibitors

Compounds of the formula (I), in which Rand Rhave the meanings indicated in Claim, are inhibitors of tyrosine kinases, in particular TIE-2, and Raf kinases, and can be employed, inter alia, for the treatment of tumours. 

Pyrazole derivatives

Compounds of the formula (I), in which R, R, R, R, Het, X and X' have the meanings indicated in claim, are inhibitors of tyrosine kinases, in particular TIE-2, and Raf kinases and can be employed, inter alia, for the treatment of tumours. 

4-Amino-5-oxo-8-phenyl-5H-pyrido(2,3-D) pyrimidine derivatives as tyrosine kinase and raf kinase inhibitors for the treatment of tumours

Compounds of the formula (I), in which R, X, R, R, Rand Rhave the meanings indicated in Claim (), are inhibitors of tyrosine kinases, in particular TIE-2, and Raf kinases and can be employed, inter alia, for the treatment of tumours. 

Pyrazole derivatives having tyrosine kinase inhibitory activity

The invention relates to compounds of formula (I) wherein R, R, R, R, R, R, R, R, R, X and X' have the designations cited in patent claim. Said compounds are inhibitors of tyrosine kinases, especially TIE-2, and Raf kinases, and can, inter alia, be used for the treatment of tumors. 

Pyridopyrimidinones

Compounds of the formula (I), in which R, R, R, Rand X have the meanings indicated in claim, are inhibitors of tyrosine kinases, in particular TIE-2, and Raf kinases and can be employed, inter alia, for the treatment of tumours. 

Sulfonamides

The invention relates to indol derivatives of Formula (I) in which R1, R2, R3, X, A, n, m and p have the meanings indicated above. 

Indol derivatives and their use as 5-HT ligands

The present invention relates to a process for the preparation of (3-cyano-1H-indol-7-yl)[4-(4-fluorophenethyl)piperazin-1-yl]-methanone and salts thereof, characterised in that an indole ester of the formula II in which R is as defined in Claim 1, is converter into 3-cyano-1H-indole-7-carboxylic acid via steps (1) to (4) according to Claim 1, and this is reacted with 1-[2-(4-fluorophenyl)ethyl]piperazine of salts thereof to give the product.

Process for the preparation of (3-cyano-1h-indol-7-yl) (4-(4-fluorophenethyl) piperazin-1-yl)-methanone and salts thereof

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Darmstadt, Germany

Helene Crassier