Da Volterra

Centre National De La Recherche Scientifique

Assistance Publique-hopitaux De Paris

Université Paris Diderot-Paris 7

Université Paris-Sud 11

Laboratoires Fournier Sa

Helene-Celine Huguet

Elias Fattal

Nicolas Tsapis

Antoine Andremont

Luc Lebreton

Olivier Lacombe

Jocelyne Annat

Compositions which deliver adsorbents, alone or in combination with active drug 'degrading molecules,' in a site-specific manner to the intestine, and which eliminate or at least lower the concentration of residual unwanted material within the intestine, and methods of treatment using the compositions, are disclosed. The compositions are ideally designed to specifically release the adsorbents in a programmed manner at a specific site of the intestinal tract. Programmed delivery prevents adsorbents from interfering with the normal absorption process of a given molecule after oral absorption, until it reaches the lower part of the small intestine. The compositions can be used to adsorb, and therefore remove, any residual drug, metabolite thereof, or bacterial toxin after oral or parenteral administration which would otherwise cause adverse effects in the lower intestine and/or colon.

Site-specific intestinal delivery of adsorbents, alone or in combination with degrading molecules

Orally administrable, site-specific (colonic), particulate delivery systems including adsorbents are disclosed. When delivered specifically to the colon, they can remove various substances present in, or as they reach, the colon. Methods of treatment using the delivery systems, and methods of preparing the delivery systems, are also disclosed. The particulate delivery systems are based on adsorbent matrices encapsulated into and/or onto particles, which selectively deliver the adsorbents to the colon. Representative drug delivery devices include pectin beads, which can optionally be crosslinked with metal ions such as zinc and/or calcium. The delivery system protects the adsorbent and prevents its adsorbing effect in the upper gastro-intestinal (GI) tract. When the particles are made from pectin, and the beads are administered to the colon, specific pectinolytic enzymes in the colon degrade the pectin, allowing the adsorbent to be released and to be fully active. Antibiotics, toxins, and other absorbable substances present in the colon will then be inactivated by adsorption into or onto the adsorbent.

Colonic delivery of adsorbents

Growing community of inventors

Paris, France

Helene-Celine Huguet