Id-fish Technology, Inc.

Helena Weltman

Jyotsna S Shah

Danuta Wronska

Nick S Harris

Suzanne Scherini-Ward

Oliva Mark

Olivia Mark

Jyotsana S Shah

Suzanne Sherini-Ward

Nick Harris

This invention relates to novel nucleic acid probes and methods for detectingparasites as well as detecting differentparasites selectively from one another.

Nucleic acid probes and methods for detecting plasmodium parasites

The present invention relates to compositions and methods for detecting Mycobacterium genus (sp.) bacteria (e.g.,) andcomplex (MAC;and) in a clinical sample or culture. The present invention also relates to differentiating cultures or samples comprising () bacteria (e.g.,) from cultures or samples comprisingcomplex (MAC;and).

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The present invention provides a method for allowing foreign particles to penetrate, very efficiently, the cell wall, cell membrane, organelle membrane and/or nuclear membrane of a cell and hybridizing or binding to the complimentary target in the cell. The cells may be from a culture or from specimens obtained from a patient. The foreign particle can be a probe consisting of, for example, either individually or in any combination of two or more of the following: DNA, RNA, peptide nucleic acids (PNA), glycopeptides, lipopeptides, glycolipids or prions. The target is a cell, a cell component or, preferably, a pathogen or pathogen component. The pathogen can be, for example, bacteria, fungi, yeast or viruses.

Method for improving cell permeability to foreign particles

This invention relates to novel nucleic acid-based probes and methods for detectingparasites in biological samples as well as detecting differentparasites selectively from one another.

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Los Altos, CA, United States of America

Helena Weltman