Case Western Reserve University

University of Texas System

Helen Moinova

Sanford D Markowitz

Amitabh Chak

Joseph Willis

Thomas LaFramboise

Joseph Ready

Jean-Pierre J Issa

Lois Myeroff

Osamu Maeda

The disclosure provides methods for storage solutions for preserving DNA methylation patterns over a period of time. The disclosure also provides for methods of using methylated DNA stored in such storage solutions.

Compositions and methods for preserving DNA methylation

The disclosure provides methods for identifying genomic loci (e.g., vimentin and/or SqBE18) that are differentially methylated in metaplasias (e.g., Barrett's esophagus) and/or neoplastic cancers (e.g., esophageal cancers). Identification of methylated genomic loci has numerous uses, including for example, to characterize disease risk, to predict responsiveness to therapy, to non-invasively diagnose subjects and to treat subjects determined to have gastrointestinal metaplasias and/or neoplasias.

Methods and compositions for detecting esophageal neoplasias and/or metaplasias in the esophagus

This application describes methods and compositions for detecting and treating C6Orf150-associated neoplasia. Differential methylation of the C6Orf150 nucleotide sequences has been observed in C6Orf150-associated neoplasia such as colon neoplasia.

Aberrant methylation of C6Orf150 DNA sequences in human colorectal cancer

Growing community of inventors

Beachwood, OH, United States of America

Helen Moinova