Massachusetts Institute of Technology

Helen L Evans

Andrew Raymond Chen

Angela N Koehler

Eric Stefan

Nicholas B Struntz

Francisco Caballero

Dylan Vijith Neel

The present disclosure provides compounds of Formula (I'), Formula (I), Formula (II), Formula (II-A), Formula (III), and Formula (IV). The compounds described herein are MAX binders and/or modulators of Myc, Mad, or Mxi1 (e.g., inhibitors of Myc, Mad, or Mxi1), and may be useful in treating a subject with a disease associated with Myc, such as proliferative diseases (e.g., cancer). Also provided in the present disclosure are pharmaceutical compositions and kits including the compounds described herein, as well as methods of using and uses of the compounds, compositions, and kits. 

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Cambridge, MA, United States of America

Helen L Evans