Merck Sharp + Dohme Corp.

Merck Sharpe & Dohme Corp.

Helen Jane Bryant

Mark Stewart Chambers

Philip Jones

Angus Murray MacLeod

Sarah Christine Hobbs

William Robert Carling

Neil Roy Curtis

Mark Stuart Chambers

Howard Barff Broughton

Robert James Maxey

The present invention provides a compound of formula (I) in which Ris generally hydrogen or CF, Ris generally hydrogen, W is a cyclic amine, a heterocycle or a group L-Y&#x2014;X where L-Y is a linking portion and X is generally an aromatic or non-aromatic heterocycle, alkyl or alkylcarbonyl and Z is generally a heterocycle such as 5-methylisoxazol-3-yl, and pharmaceutically acceptable salts thereof for enhancing cognition in conditions such as Alzheimer's Disease, pharmaceutical compositions comprising them, their use for manufacturing medicaments and methods of treatment using them 

Substituted 1,2,3-triazolo[1,5-a]quinazolines for enhancing cognition

4-oxo-tetrahydroindozole-3-carboxamide compounds according to Formula (I), or a pharmaceutically acceptable salt thereof, are GABA-A Alpha 5 ligands useful for enhancing cognition:

Tetrahydroindazole derivatives as ligands for GABA-A &agr; 5 receptors

Tetrahydroindolone derivatives as gabaaalpha5 ligands for enhancing cognition

Compounds according to Formula (I) or a salt thereof are GABA-A Alpha 5 ligands useful for enhancing cognition:

Pyrazolo&lsqb;1,5-d&rsqb;&lsqb;1,2,4&rsqb; triazines for enhancing cognition

The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof: ##STR1## wherein A, B, R2, R3 and q are as defined in the disclosure, pharmaceutical compositions containing them; methods for their production; their use in therapy and methods of treatment of disease states where cognition enhancement is required, such as Alzheimer's disease.

Substituted tetralone derivatives for enhancing cognition

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Roydon, United Kingdom

Helen Jane Bryant