Genentech, Inc.

Helen Hsifei Chen

Leonard G Presta

Napoleone Ferrara

Terri Lynn Davis-Smyth

Bidan Sinha

Aakash Mayur Mehta

Karthik Bhat

Kavitha Chandramohan

Thanh-Ha Nguyen

Fei Chen

A client device that is not originally compliant with a particular security standard (e.g., FIPS) is brought into compliance through the addition of a standard-compliant software-based cryptographic library. In order to adapt the cryptographic library to integrate with the hardware-backed keystore, a non-hardware-backed software keystore is used to store keys used by the cryptographic library. Additionally, in order to provide appropriate security for the software keystore, the software keystore (and/or the keypairs within the software keystore) is protected by a password, and the password is in turn protected by the hardware-backed keystore. Thus, to obtain the password needed to obtain a keypair from the software keystore that is in turn needed to use the cryptographic library, a user must authenticate with the operating system, e.g., by providing biometric credentials.

Implementing enhanced computer security standard for secure cryptographic key storage using a software-based keystore

The present invention is directed to novel chimeric VEGF receptor proteins comprising amino acid sequences derived from the vascular endothelial growth factor (VEGF) receptors flt-1 and KDR, including the murine homologue to the human KDR receptor FLK-1, wherein said chimeric VEGF receptor proteins bind to VEGF and antagonize the endothelial cell proliferative and angiogenic activity thereof. The present invention is also directed to nucleic acids and expression vectors encoding these chimeric VEGF receptor proteins, host cells harboring such expression vectors, pharmaceutically acceptable compositions comprising such proteins, methods of preparing such proteins and to methods utilizing such proteins for the treatment of conditions associated with undesired vascularization.

Methods of inhibiting vascular endothelial growth factor activity

Inhibitors of vascular endothelial growth factor activity

Compositions and methods for producing inhibitors of vascular endothelial growth factor activity

Methods for using inhibitors of vascular endothelial growth factor activity

The present invention is directed to novel chimeric VEGF receptor proteins comprising amino acid sequences derived from the vascular endothelial growth factor (VEGF) receptors flt-1 and KDR, including the murine homologue to the human KDR receptor FLK-1, wherein said chimeric VEGF receptor proteins bind to VEGF and antagonize the endothelial cell proliferative and anglogenic activity thereof. The present invention is also directed to nucleic acids and expression vectors encoding these chimeric VEGF receptor proteins, host cells harboring such expression vectors, pharmaceutically acceptable compositions comprising such proteins, methods of preparing such proteins and to methods utilizing such proteins for the treatment of conditions associated with undesired vascularization.

Methods for using chimeric vascular endothelial growth factor receptor proteins

Inhibitors of vascular endothelial growth factor activity, their uses and processes for their production

Receptors as novel inhibitors of vascular endothelial growth factor

The present invention is directed to novel VEGF receptor proteins comprising amino acid sequences derived from the vascular endothelial growth factor (VEGF) receptors flt-1, FLT4, and KDR, including the murine homologue to the human KDR receptor FLK-1, wherein said chimeric VEGF receptor proteins bind to VEGF and antagonize the endothelial cell proliferative and angiogenic activity thereof. The present invention is also directed to nucleic acids and expression vectors encoding these chimeric VEGF receptor proteins, host cells harboring such expression vectors, pharmaceutically acceptable compositions comprising such proteins, methods of preparing such proteins and to methods utilizing such proteins for the treatment of conditions associated with undesired vascularization.

Chimeric receptors as inhibitors of vascular endothelial growth factor

Culinary scissors

Growing community of inventors

Daly City, CA, United States of America

Helen Hsifei Chen