Hoechst Roussel Pharmaceuticals

American Hoechst Corporation

Other

Hoechst-roussel Phamraceuticals Inc.

Helen H Ong

James Arthur Profitt

Vernon B Anderson

Lawrence L Martin

Gerard J O'Malley

Mark G Palermo

Michael C Merriman

Nicholas J Hrib

Karl Schonafinger

John G Jurcak

Joseph F Payack

Joseph R Perez

Charles A Crichlow

Christine M Yasenchak

Victor J Bauer

Matthew J Flynn

There are disclosed various compounds of the formula below, ##STR1## where n, X and R.sub.1 through R.sub.4 are as defined in the specification, which are useful for alleviating various memory dysfunctions characterized by a cholinergic deficit such as Alzheimer's disease. Compounds of this invention also inhibit monoamine oxidase and/or act at central .alpha..sub.2 -adrenergic receptors, and hence are useful as antidepressants.

Substituted 1,2,3,4-tetrahydrocyclopent b!indoles, compositions and use

Substituted 1,2,3,4-tetrahydrocyclopent[b]indoles,

Novel 1-piperazinyl-2-butenes and -2-butynes, intermediates and processes for the preparation thereof, and methods of treating psychoses utilizing compounds or compositions thereof are disclosed.

1-piperazinyl-2-butenes and -2-butynes

There are disclosed various compounds of the formula below, ##STR1## wherein n, X and R.sub.1 through R.sub.4 are as defined in the specification, which are useful for alleviating various memory dysfunctions characterized by a cholinergic deficit such as Alzheimer's disease. Compounds of this invention also inhibit monoamine oxidase and/or act at central .alpha..sub.2 -adrenergic receptors, and hence are useful as antidepressants.

Select cyclopent[b]indoles

Novel aminoalkylthiodibenzoxepins, physiologically tolerable acid addition salts thereof, a method of preparing same, pharmaceutical and veterinary preparations including same and methods of treating by administering same are disclosed. These compounds are useful as analgesic, antidepressant and anticonvulsant agents. A process for selectively reducing olefins by alkaline earth metals in loweralkanols is also disclosed.

Process of reducing olefins

There are disclosed novel compounds of the formula ##STR1## where X is hydrogen, loweralkyl, loweralkoxy, hydroxy, halogen, nitro or trifluoromethyl; R.sub.1 is hydrogen or loweralkyl; R.sub.2 is hydrogen, loweralkyl, arylloweralkyl or --(CH.sub.2).sub.m R.sub.7 wherein m is 1, 2 or 3 and R.sub.7 is cyano or amino; R.sub.3 and R.sub.4 are independently hydrogen or loweralkyl; R.sub.5 and R.sub.6 are independently hydrogen or loweralkyl, or R.sub.5 +R.sub.6 taken together with the carbon atom to which they are attached constitute a cyclobutane, cyclopentane, cyclohexane, cycloheptane, pyrrolidine, piperidine, morpholine or thiomorpholine ring, or R.sub.5 is hydrogen and R.sub.6 is aryl or --CH.sub.2 OR.sub.8 wherein R.sub.8 is hydrogen, loweralkyl or loweralkylcarbonyl, which are useful for enhancing memory.

Dihydro-4(hydroxyalkyeneamino)quinolines

There are described compounds of the formula, ##STR1## where X is hydrogen, loweralkyl, loweralkoxy or halogen;

Process for (1,2,3,4-tetrahydro-9-acridinimino)cyclohexane carboxylic

Aminoalkylthiodibenzoxepins and pharmaceutical use

(1,2,3,4-Tetrahydro-9-acridinimino)cyclohexane carboxylic acid and

There are disclosed various compounds of the formula below, ##STR1## where n, X and R.sub.1 through R.sub.4 are as defined in the specification, which are useful for alleviating various memory dysfunctions characterized by a cholinergic deficit such as Alzheimer's disease. Compound of this invention also inhibit monoamine oxidase and/or act at central .alpha..sub.2 -adrenergic receptors, and hence are useful as antidepressants.

There are described compounds of the formula ##STR1## where X is hydrogen, loweralkyl, loweralkoxy or halogen;

Growing community of inventors

Whippany, NJ, United States of America

Helen H Ong